Linear thinking does not reflect the newer 21st-century anesthesia concepts. A narrative review.

Autor: Sepúlveda PO; Hospital Base San José de Osorno, Chile, Universidad Austral de Chile, Osorno, Chile. pasevou@gmail.com., Vera R; Ing. Civil Industrial, Pontificia Universidad Católica de Chile, Santiago, Chile., Fernández MS; Anesthesiology Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates., Lobo FA; Anesthesiology Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Jazyk: angličtina
Zdroj: Journal of clinical monitoring and computing [J Clin Monit Comput] 2023 Oct; Vol. 37 (5), pp. 1133-1144. Date of Electronic Publication: 2023 May 02.
DOI: 10.1007/s10877-023-01021-5
Abstrakt: The brain constitutes a good example of a chaotic, nonlinear biological system where large neuronal networks operate chaotically with random connectivity. This critical state is significantly affected by the anesthetic loss of consciousness induced by drugs whose pharmacological behavior has been classically based on linear kinetics and dynamics. Recent developments in pharmacology and brain monitoring during anesthesia suggest a different view that we tried to explore in this article. The concepts of effect-site for hypnotic drugs modeling a maximum effect, electroencephalographic dynamics during induction, maintenance, and recovery from anesthesia are discussed, integrated into this alternative view, and how it may be applied in daily clinical practice.
(© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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