Transcranial doppler velocities in a large healthy population of African children.

Autor:	O'Brien NF; Department of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital, The Ohio State University, 700 Children's Drive, Columbus, OH 43502, USA., Johnson HC; Department of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital, The Ohio State University, 700 Children's Drive, Columbus, OH 43502, USA., Musungufu DA; Centre Medicale Evangelique (CME) Bunia, Ituri District, Bunia, People's Republic of Congo., Ekandji RT; Universite des Sciences et des Technologie de Lodja (USTL), L'Hopital General de Reference de Lodja, Sankuru District, Lodja, People's Republic of Congo., Mbaka JP; Universite des Sciences et des Technologie de Lodja (USTL), L'Hopital General de Reference de Lodja, Sankuru District, Lodja, People's Republic of Congo., Babatila LK; Departement de Pediatrie, Cliniques Universitaires de Kinshasa, Hopital Pediatrique de Kalembe Lembe, Universite De Kinshasa, Kimwenza, Lembe, People's Republic of Congo., Mayindombe L; Departement de Pediatrie, Cliniques Universitaires de Kinshasa, Hopital Pediatrique de Kalembe Lembe, Universite De Kinshasa, Kimwenza, Lembe, People's Republic of Congo., Giresse B; Departement de Pediatrie, Cliniques Universitaires de Kinshasa, Hopital Pediatrique de Kalembe Lembe, Universite De Kinshasa, Kimwenza, Lembe, People's Republic of Congo., Mwanza S; Department of Paediatrics, Chipata Central Hospital, 687 and 588 Hospital Road, Chipata, Zambia., Lupumpaula C; Consultant Radiographer, Chipata Central Hospital, 687 and 588 Hospital Road, Chipata, Zambia., Chilima JS; Consultant Radiographer, Chipata Central Hospital, 687 and 588 Hospital Road, Chipata, Zambia., Nanyangwe A; Registered Nurse, University Teaching Hospitals- Children's Hospital P/BAG RW1X, Nationalist Road, Lusaka, Zambia., Kabemba P; Registered Nurse, University Teaching Hospitals- Children's Hospital P/BAG RW1X, Nationalist Road, Lusaka, Zambia., Kafula LN; Consultant Paediatric Neurologist, University Teaching Hospitals-Children's Hospital, P/BAG RW1X, Nationalist Road, Lusaka, Zambia., Chunda-Liyoka CM; Consultant Paediatric Haemotologist, University Teaching Hospitals-Children's Hospital, P/BAG RW1X, Nationalist Road, Lusaka, Zambia., Phiri T; TCD Technician, Queen Elizabeth Central Hospital, The Blantyre Malaria Project, Private Bag 360, Chichiri, Blantyre 3, Malawi., June S; TCD Technician, Queen Elizabeth Central Hospital, The Blantyre Malaria Project, Private Bag 360, Chichiri, Blantyre 3, Malawi., Gushu MB; TCD Technician, Queen Elizabeth Central Hospital, The Blantyre Malaria Project, Private Bag 360, Chichiri, Blantyre 3, Malawi., Chagaluka G; Consultant Paediatrician, Department of Pediatrics and Child Health, Kamuzu University of Health Sciences, Private Bag 360, Chichiri Blantyre 3, Malawi., Moons P; Consultant Paediatrician, Department of Pediatrics and Child Health, Kamuzu University of Health Sciences, Private Bag 360, Chichiri Blantyre 3, Malawi., Tshimanga T; Departement de Pediatrie, Cliniques Universitaires de Kinshasa, Hopital Pediatrique de Kalembe Lembe, Universite De Kinshasa, Kimwenza, Lembe, People's Republic of Congo.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2023 Apr 12; Vol. 9 (4), pp. e15419. Date of Electronic Publication: 2023 Apr 12 (Print Publication: 2023).
DOI:	10.1016/j.heliyon.2023.e15419
Abstrakt:	Background and Purpose: Transcranial doppler ultrasound (TCD) is a tool that diagnoses and monitors pathophysiological changes to the cerebrovasculature. As cerebral blood flow velocities (CBFVs) increase throughout childhood, interpretation of TCD examinations in pediatrics requires comparison to age matched normative data. Large cohorts of healthy children have not been examined to develop these reference values in any population. There is a complete absence of normative values in African children where, due to lack of alternate neuroimaging techniques, utilization of TCD is rapidly emerging. Materials and Methods: A prospective study of 710 healthy African children 3 months-15 years was performed. Demographics, vital signs, and hemoglobin values were recorded. Participants underwent a complete, non-imaging TCD examination. Systolic (Vs), diastolic (Vd), and mean (Vm) flow velocities and pulsatility index (PI) were calculated by the instrument for each measurement. Results: Vs, Vd, and Vm increased through early childhood in all vessels, with the highest CBFVs identified in children 5-5.9 years. There were few significant gender differences in CBFVs in any vessels in any age group. No correlations between blood pressure or hemoglobin and CBFVs were identified. Children in the youngest age groups had CBFVs similar to those previously published, whereas nearly every vessel in children ≥3 years had significantly lower Vs, Vd, and Vm. Conclusions: For the first time, reference TCD values for African children are established. Utilization of these CBFVs in the interpretation of TCD examinations in this population will improve the overall accuracy of TCD as a clinical tool on the continent. (© 2023 The Authors.)
Databáze:	MEDLINE
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