Does thiamine supplementation affect heart failure? A systematic review and meta-analysis of randomized control trials.

Autor: Syed ARS; Dow University of Health Science (Medicine), H#2 G#50/4/2/2 Umar banglows Abdul Rehman street garden east, Karachi, Pakistan. Electronic address: arshah321@gmail.com., Syed AA; Dow University of Health Sciences, Pakistan., Akram A; Dow University of Health Sciences, Pakistan., Azam MS; Dow University of Health Sciences, Pakistan., Muzammil MA; Dow University of Health Sciences, Pakistan., Deepak; Shaheed Mohtarma Benazir Bhuttoto Medical College Lyari, Pakistan., Ansari AI; Dow University of Health Sciences, Pakistan., Eqbal F; Dow University of Health Sciences, Pakistan., Farooq MH; Dow University of Health Sciences, Pakistan., Khatri M; Dow University of Health Sciences, Karachi, Pakistan., Kumar S; Shaheed Mohtarma Benazir Bhutto Medical College, Karachi, Pakistan., Kumar N; Detroit Medical center/Wayne state university Sinai Grace, Pakistan.
Jazyk: angličtina
Zdroj: Heart & lung : the journal of critical care [Heart Lung] 2023 Sep-Oct; Vol. 61, pp. 37-45. Date of Electronic Publication: 2023 Apr 30.
DOI: 10.1016/j.hrtlng.2023.04.011
Abstrakt: Background: Heart failure is a pathophysiological condition where decreased cardiac output is observed subsequent to any structural deformity or cessation of normal function. Thiamine deficiency is one of the risk factors responsible for causing HF; other risk factors include hypertension, smoking, and obesity.
Objective: We conducted a systemic review and meta-analysis of RCTs to scrutinize whether the heart failure patients would benefit from thiamine supplementation or not when compared to placebo.
Methods: We selected only those double-arm randomized controlled trials (RCTs) which included participants presenting with symptomatic heart failure. We excluded all the articles published in languages other than English Language. Furthermore, all the studies other than RCTs were also omitted. Articles yielded from the electronic search were exported to EndNote Reference Library software to remove any duplicates. Analyses were done using the Review manager 5.4 tool. Mean values and standard deviations were retrieved for the continuous outcomes given as raw data.
Results: The 6 RCTs selected for the statistical analysis consisted of 298 participants (158 in the intervention group, 140 in the placebo group). The outcomes resulted to be non-significant with LVEF p-value= 0.08, NT-pro BNP p-value= 0.94, LVEDV p-value= 0.53, 6MWT p-value=0.59, mortality p-value= 0.61, hospitalization p-value= 0.53 and dyspnea p-value= 0.77. Heart rate is the only significant outcome with a p-value=0.04.
Conclusion: To conclude, except for heart rate, thiamine supplementation had no effect on the outcomes of heart failure patients.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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