In-hospital and Post-discharge Status in COVID-19 Patients With Acute Respiratory Failure Supported With Extracorporeal Membrane Oxygenation.

Autor:	Galas FRBG; From the Hospital Sírio-Libanês, São Paulo, Brazil.; Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Fernandes HM; From the Hospital Sírio-Libanês, São Paulo, Brazil., Franci A; From the Hospital Sírio-Libanês, São Paulo, Brazil., Rosario AL; From the Hospital Sírio-Libanês, São Paulo, Brazil., Saretta R; From the Hospital Sírio-Libanês, São Paulo, Brazil., Patore L Jr; From the Hospital Sírio-Libanês, São Paulo, Brazil., Baracioli LM; From the Hospital Sírio-Libanês, São Paulo, Brazil.; Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Moraes JG; From the Hospital Sírio-Libanês, São Paulo, Brazil., Mourão MM; From the Hospital Sírio-Libanês, São Paulo, Brazil., Costa LDV; From the Hospital Sírio-Libanês, São Paulo, Brazil., Nascimento TCDC; From the Hospital Sírio-Libanês, São Paulo, Brazil., Drager LF; From the Hospital Sírio-Libanês, São Paulo, Brazil.; Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Dias MRS; From the Hospital Sírio-Libanês, São Paulo, Brazil., Kalil-Filho R; From the Hospital Sírio-Libanês, São Paulo, Brazil.; Instituto do Coração (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2023 May 01; Vol. 69 (5), pp. e181-e187. Date of Electronic Publication: 2023 Apr 27.
DOI:	10.1097/MAT.0000000000001919
Abstrakt:	Few data from Latin American centers on clinical outcomes in coronavirus disease 2019 (COVID-19) patients with acute respiratory distress syndrome who required extracorporeal membrane oxygenation (ECMO) are published. Moreover, clinical and functional status after hospital discharge remains poorly explored in these patients. We evaluated in-hospital outcomes of severe COVID-19 patients who received ECMO support in two Brazilian hospitals. In one-third of the survivors, post-acute COVID-19 syndrome (PACS), quality of life, anxiety, depression, and return to work were evaluated. Eighty-five patients were included and in-hospital mortality was 47%. Age >65 years (HR: 4.8; 95% confidence interval [CI]: 1.4-16.4), diabetes (HR: 6.0; 95% CI: 1.8-19.6), ECMO support duration (HR: 1.08; 95% CI: 1.05-1.12) and dialysis initiated after ECMO (HR: 3.4; 95% CI: 1.1-10.8) were independently associated with higher in-hospital mortality and mechanical ventilation (MV) duration before ECMO was not (HR: 1.18; 95% CI: 0.71-2.09). PACS-related symptoms were reported by two-thirds and half of patients at 30- and 90-days post-discharge, respectively. The median EQ-5D score was 0.85 (0.70-1.00) and 0.77 (0.66-1.00) at 30 and 90 days. Of the 15 responders, all previously working patients, except one, have returned to work at 90 days. In conclusion, in-hospital mortality in a large Latin American cohort was comparable to the Global extracorporeal life support organization registry. Competing Interests: Disclosure: The authors have no conflicts of interest to report. (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the ASAIO.)
Databáze:	MEDLINE
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