Advanced injectable hydrogels for bone tissue regeneration.

Autor: A Alamir HT; College of Pharmacy, University of Al-Ameed, Karbala, Iraq., Ismaeel GL; College of Pharmacy, University of Al-Ameed, Karbala, Iraq., Jalil AT; Medical Laboratories Techniques Department, Al-Mustaqbal University College, Hilla, Babylon, 51001 Iraq., Hadi WH; National University of Science and Technology, Dhi Qar, Iraq., Jasim IK; Department of Pharmacology, Al-Turath University College, Baghdad, Iraq., Almulla AF; Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq., Radhea ZA; Medical Technical College, Al-Farahidi University, Baghdad, Iraq.
Jazyk: angličtina
Zdroj: Biophysical reviews [Biophys Rev] 2023 Apr 13; Vol. 15 (2), pp. 223-237. Date of Electronic Publication: 2023 Apr 13 (Print Publication: 2023).
DOI: 10.1007/s12551-023-01053-w
Abstrakt: Diseases or defects of the skeleton are hazardous because of their specificity and intricacy. Bone tissue engineering has become an important area of research that offers promising new tools for making biomimetic hydrogels that can be used to treat bone diseases. New hydrogels with a distinctive 3D network structure, high water content, and functional capabilities are ranked among the most promising candidates for bone tissue engineering. This makes them helpful in treating cartilage injury, skull deformity, and arthritis. This review will briefly introduce the variety of biocompatible functional hydrogels used in cell culture and bone tissue regeneration. Many gel design concepts, such as crosslinking procedures, controlled release properties, and alternative bionic methodology, were stressed regarding injectable hydrogels to form bone tissue. Hydrogels manufactured from biocompatible materials are a promising option for minimally invasive surgery because of their adaptable physicochemical qualities, ability to fill irregularly shaped defect sites, and ability to grow hormones or release drugs in response to external stimuli. Also included in this overview is a quick rundown of the more practical designs employed in treating bone disorders. Essential details on injectable hydrogel scaffolds for bone tissue regeneration are described in this article.
Competing Interests: Competing interestsThe authors declare no competing interests.
(© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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