Deoxyglucose-conjugated persistent luminescent nanoparticles for theragnostic application in fibrosarcoma tumor model.

Autor:	Sharma KS; Chemistry Division, Bhabha Atomic Research Centre Mumbai 400085 India rsn@barc.gov.in., Melwani PK; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre Mumbai 400085 India bnp@barc.gov.in.; Homi Bhabha National Institute Anushakti Nagar Mumbai 400094 India., Yadav HD; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre Mumbai 400085 India bnp@barc.gov.in., Joshi R; Chemistry Division, Bhabha Atomic Research Centre Mumbai 400085 India rsn@barc.gov.in.; Homi Bhabha National Institute Anushakti Nagar Mumbai 400094 India., Shetake NG; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre Mumbai 400085 India bnp@barc.gov.in.; Homi Bhabha National Institute Anushakti Nagar Mumbai 400094 India., Dubey AK; Bio-organic Division, Bhabha Atomic Research Centre Mumbai 400085 India., Singh BP; Chemistry Division, Bhabha Atomic Research Centre Mumbai 400085 India rsn@barc.gov.in., Phapale S; Chemistry Division, Bhabha Atomic Research Centre Mumbai 400085 India rsn@barc.gov.in., Phadnis PP; Chemistry Division, Bhabha Atomic Research Centre Mumbai 400085 India rsn@barc.gov.in.; Homi Bhabha National Institute Anushakti Nagar Mumbai 400094 India., Vatsa RK; Chemistry Division, Bhabha Atomic Research Centre Mumbai 400085 India rsn@barc.gov.in.; Homi Bhabha National Institute Anushakti Nagar Mumbai 400094 India., Ningthoujam RS; Chemistry Division, Bhabha Atomic Research Centre Mumbai 400085 India rsn@barc.gov.in.; Homi Bhabha National Institute Anushakti Nagar Mumbai 400094 India., Pandey BN; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre Mumbai 400085 India bnp@barc.gov.in.; Homi Bhabha National Institute Anushakti Nagar Mumbai 400094 India.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2023 Apr 28; Vol. 13 (19), pp. 13240-13251. Date of Electronic Publication: 2023 Apr 28 (Print Publication: 2023).
DOI:	10.1039/d3ra01169k
Abstrakt:	Deoxyglucose conjugated nanoparticles with persistent luminescence have shown theragnostic potential. In this study, deoxyglucose-conjugated nano-particles with persistent luminescence properties were synthesized, and their theragnostic potential was evaluated in fibrosarcoma cancer cells and a tumor model. The uptake of nano-formulation was found to be higher in mouse fibrosarcoma (WEHI-164) cells cultured in a medium without glucose. Nanoparticles showed a higher killing ability for cancer cells compared to normal cells. A significant accumulation of nanoparticles to the tumor site in mice was evident by the increased tumor/normal leg ratio, resulting in a significant decrease in tumor volume and weight. Histopathological studies showed a significant decrease in the number of dividing mitotic cells but a greater number of apoptotic/necrotic cells in nanoparticle-treated tumor tissues, which was correlated with a lower magnitude of Ki-67 expression (a proliferation marker). Consequently, our results showed the potential of our nano-formulation for cancer theragnosis. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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