Organic-inorganic hybrid salt and mixed ligand Cr(III) complexes containing the natural flavonoid chrysin: Synthesis, characterization, computational, and biological studies.
| Autor: | Alem MB; Department of Applied Chemistry, Adama Science and Technology University, Adama, Ethiopia., Desalegn T; Department of Applied Chemistry, Adama Science and Technology University, Adama, Ethiopia., Damena T; Department of Chemistry, Wachemo University, Hossana, Ethiopia., Bayle EA; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, Taiwan.; Department of Chemistry, Debre Markos University, Debre Markos, Ethiopia., Koobotse MO; School of Allied Health Professions, University of Botswana, Gaborone, Botswana., Ngwira KJ; Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Johannesburg, South Africa., Ombito JO; Department of Chemistry, University of Botswana, Gaborone, Botswana., Zachariah M; School of Allied Health Professions, University of Botswana, Gaborone, Botswana., Demissie TB; Department of Chemistry, University of Botswana, Gaborone, Botswana. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in chemistry [Front Chem] 2023 Apr 12; Vol. 11, pp. 1173604. Date of Electronic Publication: 2023 Apr 12 (Print Publication: 2023). |
| DOI: | 10.3389/fchem.2023.1173604 |
| Abstrakt: | Organic-inorganic hybrid salt and mixed ligand Cr(III) complexes ( Cr1 and Cr2 ) containing the natural flavonoid chrysin were synthesized. The metal complexes were characterized using UV-Vis, Fourier-transform infrared, MS, SEM-EDX, XRD, and molar conductance measurements. Based on experimental and DFT/TD-DFT calculations, octahedral geometries for the synthesized complexes were suggested. The powder XRD analysis confirms that the synthesized complexes were polycrystalline, with orthorhombic and monoclinic crystal systems having average crystallite sizes of 21.453 and 19.600 nm, percent crystallinities of 51% and 31.37%, and dislocation densities of 2.324 × 10 -3 and 2.603 × 10 -3 nm -2 for Cr1 and Cr2 , respectively. The complexes were subjected to cytotoxicity, antibacterial, and antioxidant studies. The in vitro biological studies were supported with quantum chemical and molecular docking computational studies. Cr1 showed significant cytotoxicity to the MCF-7 cell line, with an IC Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Alem, Desalegn, Damena, Bayle, Koobotse, Ngwira, Ombito, Zachariah and Demissie.) |
| Databáze: | MEDLINE |
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