Atorvastatin Improves the Propionic Acid-Induced Autism in Rats: The Roles of Sphingosine-1-Phosphate and Anti-inflammatory Action.

Autor:	Durankuş F; Medical Education, Medeniyet University, İstanbul, TUR., Budak K; Medicine, Tekirdağ Namık Kemal University, Tekirdağ, TUR., Albayrak Y; Medical Education, Tekirdağ Namık Kemal University, Tekirdağ, TUR., Sever İH; Medicine, Demiroğlu Bilim University, İstanbul, TUR., Özkul B; Medicine, İstanbul Atlas University, İstanbul, TUR., Uyanıkgil Y; Histology and Embryology, Ege University Faculty of Medicine, Izmir, TUR., Albayrak N; Medicine, Çorlu State Hospital, Tekirdağ, TUR., Erbas O; Department of Physiology, Istanbul Bilim University School of Medicine, Istanbul, TUR.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Mar 29; Vol. 15 (3), pp. e36870. Date of Electronic Publication: 2023 Mar 29 (Print Publication: 2023).
DOI:	10.7759/cureus.36870
Abstrakt:	Purpose The aim of this study is to investigate the benefits of atorvastatin on the propionic acid-induced autism model via increasing sphingosine-1-phosphate and anti-inflammatory actions with imaging and brain tissue investigations. Materials and methods Twenty-five mg/kg/day/rat of propionic acid (PPA) was administered intraperitoneally to 20 male Wistar rats, and 10 male Wistar rats were fed orally. Study groups were designed as follows: Group 1: Control Group (orally fed control, n=10); Group 2 (PPA+saline, n=10); Group 3 (PPA+Atorvastatin, n=10). The brain biochemical and histopathology assessments and magnetic resonance (MR) imaging were conducted across groups in order to compare them. Results The PPA+Atorvastatin group was found to have significantly lower levels of brain malondialdehyde, IL-2 level, IL-17, tumor necrosis factor-alpha (TNF-α), and lactate compared to the PPA+saline group. The PPA+Atorvastatin group had higher levels of nerve growth factor and nuclear factor erythroid 2-related factor 2 (NRF-2) and sphingosine-1-phosphate. In histopathology assessments, the PPA+Atorvastatin group was found to have significantly higher neuronal counts of CA1 and CA2 in the hippocampus, and Purkinje cells in the cerebellum. Conclusions Current findings suggest that atorvastatin increases sphingosine-1-phosphate levels and decreases inflammatory actions which characterize the autism rodent model implemented in this study. These preliminary results have to be confirmed by further experimental and clinical studies. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Durankuş et al.)
Databáze:	MEDLINE
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