Assessment of Role of Platelet Indices in the Occurrence of Retinopathy of Prematurity.

Autor: Reddy RM; Department of Ophthalmology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India., Bhandary SV; Department of Ophthalmology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India., Rao KA; Department of Ophthalmology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India., Lewis LE; Department of Paediatrics, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India., Lal SM; Center for Pharmacometrics and Molecular Discovery, Union University School of Pharmacy, Tennessee, USA., Rachel NM; Department of Ophthalmology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Jazyk: angličtina
Zdroj: Middle East African journal of ophthalmology [Middle East Afr J Ophthalmol] 2023 Feb 24; Vol. 29 (2), pp. 91-95. Date of Electronic Publication: 2023 Feb 24 (Print Publication: 2022).
DOI: 10.4103/meajo.meajo_246_21
Abstrakt: Purpose: Platelets have a major role in the regulation of angiogenesis. Platelets have proangiogenic factors like vascular endothelial growth factor, which causes neovascularization of immature retina. However, there is no conclusive evidence to show that platelet indices have a role in retinopathy of prematurity (ROP). This study is aimed at assessing the role of platelet indices in the occurrence and need for treatment of ROP.
Methods: This prospective cohort study included the screening of preterm babies (<37 weeks of gestation with birth weight <2000 g). The samples of platelet indices (mean platelet volume [MPV], platelet count [PLT], plateletcrit [PCT], and platelet distribution width [PDW]) collected within 1 st week of life were obtained from the electronic medical records and correlated to ROP status. Statistical analysis was done using SPSS version 22, and the Chi-square test and odds ratio were used for analysis.
Results: A total of 300 preterm babies were screened, of whom, 55 (18.3%) babies had ROP changes. The association of the presence of ROP changes and platelet indices was not statistically significant ( P value being MPV [0.22], PLT [0.58], PCT [0.98], and PDW [0.17]). Similarly, the requirement of treatment for ROP (Type I ROP) could not be correlated with abnormal platelet indices (odds ratio at 95% confidence interval - MPV [6 (0.44-81.44)], PLT [1.7 (0.25-11.37)], PCT [3 (0.44-20.90)], and PDW [0.32 (0.33-3.05)]).
Conclusion: Abnormal platelet indices did not show any significant risk with the occurrence or need for treatment of ROP.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2023 Middle East African Journal of Ophthalmology.)
Databáze: MEDLINE
Externí odkaz: