Prognostic significance of mucinous histology in left‑sided metastatic colorectal cancers with wild‑type RAS and evaluation of backbone chemotherapy regimens.

Autor: Arikan R; Department of Internal Medicine, Division of Medical Oncology, Marmara University School of Medicine, Istanbul 34899, Turkey., Atci MM; Department of Internal Medicine, Division of Medical Oncology, Professor Dr Cemil Tascioglu City Hospital, Istanbul 34384, Turkey., Ay S; Department of Internal Medicine, Division of Medical Oncology, Medeniyet University, School of Medicine, Istanbul 34722, Turkey., Ayhan M; Department of Internal Medicine, Division of Medical Oncology, Istanbul Kartal Lutfi Kirdar Education and Training Hospital, Istanbul 34865, Turkey., Demircan NC; Department of Internal Medicine, Division of Medical Oncology, Marmara University School of Medicine, Istanbul 34899, Turkey., Telli TA; Department of Internal Medicine, Division of Medical Oncology, Marmara University School of Medicine, Istanbul 34899, Turkey., Çelebi A; Department of Internal Medicine, Division of Medical Oncology, Marmara University School of Medicine, Istanbul 34899, Turkey., Yaşar A; Department of Internal Medicine, Division of Medical Oncology, Marmara University School of Medicine, Istanbul 34899, Turkey., Işik S; Department of Internal Medicine, Division of Medical Oncology, Marmara University School of Medicine, Istanbul 34899, Turkey., Celikel C; Department of Pathology, Marmara University School of Medicine, Istanbul 34899, Turkey., Balvan O; Department of Internal Medicine, Division of Medical Oncology, Marmara University School of Medicine, Istanbul 34899, Turkey., Bayoglu IV; Department of Internal Medicine, Division of Medical Oncology, Marmara University School of Medicine, Istanbul 34899, Turkey., Kostek O; Department of Internal Medicine, Division of Medical Oncology, Marmara University School of Medicine, Istanbul 34899, Turkey., Dane F; Department of Internal Medicine, Division of Medical Oncology, Acıbadem University School of Medicine, Istanbul 34758, Turkey., Yumuk PF; Department of Internal Medicine, Division of Medical Oncology, Koc University School of Medicine, Istanbul 34010, Turkey.
Jazyk: angličtina
Zdroj: Oncology letters [Oncol Lett] 2023 Apr 05; Vol. 25 (5), pp. 208. Date of Electronic Publication: 2023 Apr 05 (Print Publication: 2023).
DOI: 10.3892/ol.2023.13795
Abstrakt: Mucinous colorectal adenocarcinoma (MCAC) is a distinct subtype of colorectal carcinoma (CRC). The prognostic and predictive significance of mucinous histology remains controversial. It was aimed to investigate the prognostic and/or predictive role of mucinous histology in left-sided metastatic CRC (mCRC) with wild-type RAS. This is a retrospective multicenter study of mCRC treated with first line anti-EGFR combined 5-fluorouracil based chemotherapy (CT). Patients were stratified according to presence (>50% extracellular mucin) or absence of mucinous histology. Survival analyses were performed firstly regardless of treatment options and then performed as separating according to CT regimens. Additional analyses were performed for MCAC patients considering backbone CT regimens. A total of 125 patients were included, consisting of 40 (32.0%) patients with MCAC and 85 (68.0%) patients with non-MCAC. Median follow-up time was 19.7 months. Median progression-free survival (PFS) was 10.7 months in all patients, and PFS was lower in MCAC than non-MCAC (9.9 vs. 12.0 months, respectively, P=0.005). Median overall survival (OS) was 25.7 months in all patients. OS was lower in MCAC than non-MCAC (22.8 vs. 29.7 months, respectively, P=0.005). When considering backbone CT regimens, in multivariate analyses, mucinous histology was an independent prognostic factor for OS in both for mFOLFOX6 (HR: 1.92, P=0.04) and FOLFIRI (HR: 2.04, P=0.04) groups and was associated with poor PFS in only mFOLFOX6 (HR: 3.86, P<0.001) group. When outcomes were analyzed for the MCAC group, median OS of MCAC patients receiving mFOLFOX6 and FOLFIRI was 22.47 and 14.22 months, respectively (P=0.41). Median PFS of MCAC patients receiving mFOLFOX6 and FOLFIRI was 10.15 and 8.11 months, respectively (P=0.73). The study revealed poor prognosis of mucinous histology, both in whole study population and in backbone CT groups. Moreover, lower PFS of MCAC patients was revealed in only mFOLFOX6 group and this finding may be a valuable issue for the future research. However, considering all analyses, the present results did not indicate a special benefit of any backbone CT regimen for MCAC patients.
Competing Interests: The authors declare that they have no competing interests.
(Copyright: © Arikan et al.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje