An updated overview of cyanidins for chemoprevention and cancer therapy.

Autor: Posadino AM; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy., Giordo R; College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, 505055 Dubai, United Arab Emirates., Ramli I; Département de Biologie Animale, Université des frères Mentouri Constantine 1, 25000 Constantine, Algeria., Zayed H; Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar., Nasrallah GK; Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar., Wehbe Z; Vascular Biology Research Centre, Molecular and Clinical Research Institute, University of London, London, United Kingdom., Eid AH; Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar., Gürer ES; Sivas Cumhuriyet University, Faculty of Pharmacy, Department of Pharmacognosy, Sivas, Turkey., Kennedy JF; Chembiotech Laboratories, Advanced Science and Technology Institute, Kyrewood House, Tenbury Wells, Worcs WR15 8FF, UK., Aldahish AA; Department of Pharmacology & Toxicology, College of Pharmacy, King Khalid University, Abha 62529, Asir, Saudi Arabia., Calina D; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. Electronic address: calinadaniela@gmail.com., Razis AFA; Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. Electronic address: madfaizal@upm.edu.my., Modu B; Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Department of Biochemistry, Faculty of Science, University of Maiduguri, 1069 Maiduguri, Borno state, Nigeria., Habtemariam S; Pharmacognosy Research & Herbal Analysis Services UK, University of Greenwich, Central Avenue, Chatham-Maritime, Kent ME4 4TB, UK., Sharifi-Rad J; Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador. Electronic address: javad.sharifirad@gmail.com., Pintus G; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy; Department of Medical Laboratory Sciences, College of Health Sciences, and Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates. Electronic address: gpintus@uniss.it., Cho WC; Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong. Electronic address: chocs@ha.org.hk.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2023 Jul; Vol. 163, pp. 114783. Date of Electronic Publication: 2023 Apr 28.
DOI: 10.1016/j.biopha.2023.114783
Abstrakt: Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long time. The most common and abundant anthocyanins are those presenting an O-glycosylation at C-3 (C ring) of the flavonoid skeleton to form -O-β-glucoside derivatives. The present comprehensive review summarized recent data on the anticancer properties of cyanidings along with natural sources, phytochemical data, traditional medical applications, molecular mechanisms and recent nanostrategies to increase the bioavailability and anticancer effects of cyanidins. For this analysis, in vitro, in vivo and clinical studies published up to the year 2022 were sourced from scientific databases and search engines such as PubMed/Medline, Google scholar, Web of Science, Scopus, Wiley and TRIP database. Cyanidins' antitumor properties are exerted during different stages of carcinogenesis and are based on a wide variety of biological activities. The data gathered and discussed in this review allows for affirming that cyanidins have relevant anticancer activity in vitro, in vivo and clinical studies. Future research should focus on studies that bring new data on improving the bioavailability of anthocyanins and on conducting detailed translational pharmacological studies to accurately establish the effective anticancer dose in humans as well as the correct route of administration.
Competing Interests: Conflict of interest statement The authors declare that they have no conflict of interest.
(Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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