Predicting short-term and long-term mortalities from sepsis in patients who receive allogeneic haematopoietic stem cell transplantation.

Autor: Wu YJ; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Liu HX; Department of Clinical Epidemiology and biostatistics, Peking University People's Hospital, Beijing, China., Zhu XL; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Fu HX; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., He Y; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Wang FR; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Zhang YY; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Mo XD; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Han W; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Wang JZ; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Wang Y; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Chen H; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Chen YH; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Zhao XY; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Chang YJ; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Xu LP; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Liu KY; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Huang XJ; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China., Zhang XH; Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.; Collaborative Innovation Center of Hematology, Peking University, Beijing, China.; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.; National Clinical Research Center for Hematologic Disease, Beijing, China.
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2023 Jul; Vol. 202 (2), pp. 344-355. Date of Electronic Publication: 2023 Apr 29.
DOI: 10.1111/bjh.18835
Abstrakt: Patients who receive allogeneic haematopoietic stem cell transplantation (allo-HSCT) may develop sepsis, which result in a highly intensive care unit admission rate and mortality. Therefore, short-term and long-term prognostic models for sepsis after allo-HSCT are urgently needed. We enrolled patients receiving allo-HSCT who developed sepsis after allo-HSCT at Peking University People's Hospital between 2012 and 2021, including 287 patients who received allo-HSCT in 2018-2021 in the derivation cohort, and 337 patients in 2012-2017 in the validation cohort. Multivariate logistic regression analysis was used to identify prognostic factors, and these identified factors were incorporated into two scoring models. Seven independent factors (acute graft-versus-host disease (GVHD), chronic GVHD (cGVHD), total bilirubin, lactate dehydrogenase (LDH) and organ dysfunction [renal, lung and heart]) were included in the 6-month prognostic model, and six factors (cGVHD, C-reactive protein, LDH, organ dysfunction [lung, neurologic and coagulation]) were included in the 14-day prognostic model. The area under the receiver operating characteristic curves, calibration plots and decision curve analysis demonstrated the robust predictive performance of the models, better than the Sequential Organ Failure Assessment score. Early identification of patients with high risk of 6-month and 14-day death may allow clinicians to provide timely treatments and improve the therapeutic effects.
(© 2023 British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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