Exposure to negative socio-emotional events induces sustained alteration of resting-state brain networks in older adults.

Autor: Baez-Lugo S; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland. sebastian.baezlugo@unige.ch.; Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland. sebastian.baezlugo@unige.ch., Deza-Araujo YI; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland.; Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland., Maradan C; Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland., Collette F; GIGA-CRC In Vivo Imaging Research Unit, University of Liège, Liège, Belgium., Lutz A; EDUWELL team, Lyon Neuroscience Research Centre (INSERM U1028, CNRS UMR5292, Lyon 1 University), Lyon, France., Marchant NL; Division of Psychiatry, University College London, London, UK., Chételat G; Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1237, GIP Cyceron, Caen, France., Vuilleumier P; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland. patrik.vuilleumier@unige.ch.; Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland. patrik.vuilleumier@unige.ch., Klimecki O; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland. olga.klimecki@unige.ch.; Deutsches Zentrum für Neurodegenerative Erkrankungen, Dresden, Germany. olga.klimecki@unige.ch.
Jazyk: angličtina
Zdroj: Nature aging [Nat Aging] 2023 Jan; Vol. 3 (1), pp. 105-120. Date of Electronic Publication: 2023 Jan 12.
DOI: 10.1038/s43587-022-00341-6
Abstrakt: Basic emotional functions seem well preserved in older adults. However, their reactivity to and recovery from socially negative events remain poorly characterized. To address this, we designed a 'task-rest' paradigm in which 182 participants from two independent experiments underwent functional magnetic resonance imaging while exposed to socio-emotional videos. Experiment 1 (N = 55) validated the task in young and older participants and unveiled age-dependent effects on brain activity and connectivity that predominated in resting periods after (rather than during) negative social scenes. Crucially, emotional elicitation potentiated subsequent resting-state connectivity between default mode network and amygdala exclusively in older adults. Experiment 2 replicated these results in a large older adult cohort (N = 127) and additionally showed that emotion-driven changes in posterior default mode network-amygdala connectivity were associated with anxiety, rumination and negative thoughts. These findings uncover the neural dynamics of empathy-related functions in older adults and help understand its relationship to poor social stress recovery.
(© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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