The Newfoundland and Labrador mosaic founder population descends from an Irish and British diaspora from 300 years ago.

Autor:	Gilbert E; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland. edmundgilbert@rcsi.ie.; FutureNeuro SFI Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland. edmundgilbert@rcsi.ie., Zurel H; Sequence Bioinformatics, Inc., St. John's, Newfoundland and Labrador, Canada., MacMillan ME; Sequence Bioinformatics, Inc., St. John's, Newfoundland and Labrador, Canada., Demiriz S; Sequence Bioinformatics, Inc., St. John's, Newfoundland and Labrador, Canada., Mirhendi S; Sequence Bioinformatics, Inc., St. John's, Newfoundland and Labrador, Canada., Merrigan M; Genealogical Society of Ireland, Dún Laoghaire, Ireland., O'Reilly S; Genealogical Society of Ireland, Dún Laoghaire, Ireland., Molloy AM; School of Medicine, Trinity College, Dublin, Ireland., Brody LC; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Bodmer W; Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK., Leach RA; Sequence Bioinformatics, Inc., St. John's, Newfoundland and Labrador, Canada., Scott REM; Sequence Bioinformatics, Inc., St. John's, Newfoundland and Labrador, Canada., Mugford G; Sequence Bioinformatics, Inc., St. John's, Newfoundland and Labrador, Canada., Randhawa R; Sequence Bioinformatics, Inc., St. John's, Newfoundland and Labrador, Canada., Stephens JC; Sequence Bioinformatics, Inc., St. John's, Newfoundland and Labrador, Canada., Symington AL; Sequence Bioinformatics, Inc., St. John's, Newfoundland and Labrador, Canada., Cavalleri GL; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.; FutureNeuro SFI Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland., Phillips MS; Sequence Bioinformatics, Inc., St. John's, Newfoundland and Labrador, Canada.
Jazyk:	angličtina
Zdroj:	Communications biology [Commun Biol] 2023 Apr 28; Vol. 6 (1), pp. 469. Date of Electronic Publication: 2023 Apr 28.
DOI:	10.1038/s42003-023-04844-9
Abstrakt:	The founder population of Newfoundland and Labrador (NL) is a unique genetic resource, in part due to its geographic and cultural isolation, where historical records describe a migration of European settlers, primarily from Ireland and England, to NL in the 18th and 19th centuries. Whilst its historical isolation, and increased prevalence of certain monogenic disorders are well appreciated, details of the fine-scale genetic structure and ancestry of the population are lacking. Understanding the genetic origins and background of functional, disease causing, genetic variants would aid genetic mapping efforts in the Province. Here, we leverage dense genome-wide SNP data on 1,807 NL individuals to reveal fine-scale genetic structure in NL that is clustered around coastal communities and correlated with Christian denomination. We show that the majority of NL European ancestry can be traced back to the south-east and south-west of Ireland and England, respectively. We date a substantial population size bottleneck approximately 10-15 generations ago in NL, associated with increased haplotype sharing and autozygosity. Our results reveal insights into the population history of NL and demonstrate evidence of a population conducive to further genetic studies and biomarker discovery. (© 2023. The Author(s).)
Databáze:	MEDLINE
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