Serum levels of erythropoietin in patients with chronic obstructive pulmonary disease and anemia.

Autor: Rezvani A; Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.; Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Science, Shiraz, Iran., Masoompour SM; Non-communicable Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Azarpira N; Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Monjazeb R; Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran., Akbarzadeh M; Department of Internal Medicine, Lar University of Medical Sciences, Lar, Iran., Salimi M; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran., Shahriarirad R; Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Science, Shiraz, Iran. R.shahriari1995@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Apr 28; Vol. 13 (1), pp. 6990. Date of Electronic Publication: 2023 Apr 28.
DOI: 10.1038/s41598-023-34290-w
Abstrakt: The important association of erythropoietin (EPO) serum levels and chronic obstructive pulmonary disease (COPD) with anemia has been inadequately studied and remains a controversial issue. We aimed to shed light on this matter by comparing EPO levels in anemic and non-anemic COPD patients, along with a review of published literature. This cross-sectional study was conducted on COPD patients referred to the pulmonary clinic of Shahid Faghihi Hospital and Motahari clinic, Shiraz, Iran, for one year. We measured complete blood count, red blood cell indices, serum iron, TIBC and ferritin levels, serum EPO levels, and body mass index. Among 35 patients in this study, 28 males and 7 females were enrolled with a mean age of 54.57 ± 8.07 years. The average Forced expiratory volume in first second (FEV1) was 37.26 ± 7.33% and FEV1/FVC was 0.46 ± 0.12. Mean EPO levels were 30.29 ± 2.066 mU/mL. No statistically significant association was observed among erythropoietin levels and Hb, COPD severity, and age. There was no significant difference in EPO levels between anemic and non-anemic patients. EPO level, against the traditional expectation, didn't increase in COPD patients. EPO production also didn't compensate for the anemia of chronic disease which considers as a common comorbid disorder in these patients.
(© 2023. The Author(s).)
Databáze: MEDLINE
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