Annexins A2 and A5 are potential early biomarkers of hepatocarcinogenesis.

Autor: Herrera-López EE; Laboratorio de Enfermedades Hepáticas, Instituto Nacional de Medicina Genómica, Periférico Sur No. 4809, Col. Arenal Tepepan, Alcaldía Tlalpan, D.F., 14610, Mexico City, Mexico.; Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del IPN, Avenida Instituto Politécnico Nacional 2508, 07360, Mexico City, Mexico., Guerrero-Escalera D; Laboratorio de Enfermedades Hepáticas, Instituto Nacional de Medicina Genómica, Periférico Sur No. 4809, Col. Arenal Tepepan, Alcaldía Tlalpan, D.F., 14610, Mexico City, Mexico., Aguirre-Maldonado I; Laboratorio de Enfermedades Hepáticas, Instituto Nacional de Medicina Genómica, Periférico Sur No. 4809, Col. Arenal Tepepan, Alcaldía Tlalpan, D.F., 14610, Mexico City, Mexico.; Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del IPN, Avenida Instituto Politécnico Nacional 2508, 07360, Mexico City, Mexico., López-Hernández A; Laboratorio de Enfermedades Hepáticas, Instituto Nacional de Medicina Genómica, Periférico Sur No. 4809, Col. Arenal Tepepan, Alcaldía Tlalpan, D.F., 14610, Mexico City, Mexico., Montero H; Instituto de Salud Pública, Universidad Veracruzana, Veracruz, Mexico., Gutiérrez-Nava MA; División de Ciencias Biológicas y de la Salud, Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Mexico City, Mexico., Del Pozo-Yauner L; Department of Pathology, College of Medicine, University of South Alabama, Alabama, USA., Arellanes-Robledo J; Laboratorio de Enfermedades Hepáticas, Instituto Nacional de Medicina Genómica, Periférico Sur No. 4809, Col. Arenal Tepepan, Alcaldía Tlalpan, D.F., 14610, Mexico City, Mexico.; Dirección de Cátedras, Consejo Nacional de Ciencia y Tecnología, Mexico City, Mexico., Camacho J; Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del IPN, Avenida Instituto Politécnico Nacional 2508, 07360, Mexico City, Mexico., Pérez-Carreón JI; Laboratorio de Enfermedades Hepáticas, Instituto Nacional de Medicina Genómica, Periférico Sur No. 4809, Col. Arenal Tepepan, Alcaldía Tlalpan, D.F., 14610, Mexico City, Mexico. jiperez@inmegen.gob.mx.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Apr 28; Vol. 13 (1), pp. 6948. Date of Electronic Publication: 2023 Apr 28.
DOI: 10.1038/s41598-023-34117-8
Abstrakt: Hepatocellular carcinoma (HCC) is a highly lethal liver cancer with late diagnosis; therefore, the identification of new early biomarkers could help reduce mortality. We determine the tissue and plasma status of five annexins during hepatocarcinogenesis by diethylnitrosamine-induced cirrhosis-HCC. We found that Anxa5 was the earliest upregulated gene at week 12 after HCC initiation, while Anxa1 and Anxa2 were upregulated in advanced HCC stages (weeks 18 and 22). Furthermore, the protein level of Annexin A1, A2, A5 and A10 was increased from the early stages. Immunofluorescence and subcellular fractionation revealed Annexin A1, A2, and A5 in the cytoplasm and nuclei of tumor cells. Notably, increased plasma levels of Annexin A5 significantly (r 2  = 0.8203) correlated with Annexin A5 levels in liver tissue from week 12 and gradually increased until week 22. Using the TCGA database, we found that the expression of ANXA2 (HR = 1.7, p = 0.0046) and ANXA5 (HR = 1.8, p = 0.00077) was associated with poor survival in HCC patients. In conclusion, we have identified Annexin A1 and A5 as potentially useful early biomarkers for poor prognosis in HCC patients.
(© 2023. The Author(s).)
Databáze: MEDLINE
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