Assessment of the appropriateness of antibiotic prescribing in an acute UK hospital using a national audit tool: a single centre retrospective survey.

Autor:	Owens R; Emergency Department, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK rhys.owens@nhs.net., Bamford K; Medical Microbiology, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Pinion S; Anaesthetics, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Garry E; Department of Obstetrics and Gynaecology, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Cranmer E; Eldercare, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Pearce C; Respiratory department, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Wint HH; Neurology department, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Gill S; Respiratory department, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Philips R; Acute Medicine, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Khan A; Eldercare, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Roy Bentley S; Enhanced Perioperative Care Unit, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Roberts N; University Hositals Plymouth NHS Trust, Plymouth, UK., Keating B; Acute Medicine, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Askaroff N; Oncology Department, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Morphew M; Oncology, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Orr C; Emergency Department, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Mouket T; Acute Medicine, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Pope K; Acute Medicine, Royal Cornwall Hospitals NHS Trust, Truro, Cornwall, UK., Powell N; Pharmacy Department, Royal Cornwall Hospital NHS Trust, Cornwall, UK.
Jazyk:	angličtina
Zdroj:	European journal of hospital pharmacy : science and practice [Eur J Hosp Pharm] 2024 Oct 25; Vol. 31 (6), pp. 505-510. Date of Electronic Publication: 2024 Oct 25.
DOI:	10.1136/ejhpharm-2022-003569
Abstrakt:	Introduction: Antibiotic use drives antibiotic resistance. The UK antimicrobial resistance (AMR) strategy aims to reduce antibiotic use. We aimed to quantify excess antibiotic use in a district general hospital in south-west England. Methods: Medical patients discharged in August 2020 who had received antibiotics were included. An audit tool of antibiotic prescribing appropriateness was used to collect relevant clinical information regarding each patient case. The appropriateness of antibiotic use was then determined by two infection specialists and excess days of therapy (DOTs) calculated. Results: 647 patients were discharged in August 2020. Of the 1658 antibiotic DOTs for the 184 patients reviewed, 403 (24%) were excess DOTs. The excess antibiotic DOTs were prescribed in 92 patients (50%); 112/403 (27.8%) excess DOTs originated at the initiation of antibiotic therapy (time point A); 184/403 (45.7%) of excess DOTs occurred at the antibiotic review pre-72 hours (time point B); and 107/403 (26.6%) of excess DOTs were due to protracted antibiotic courses (time point C). Conclusion: 24% of antibiotic DOTs were deemed unnecessary. The greatest opportunity to reduce antibiotic use safely was the pre-72 hours antibiotic review, which may provide a target for reducing excess antimicrobial therapy in line with the national AMR strategy. Competing Interests: Competing interests: None declared. (© European Association of Hospital Pharmacists 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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