The effects of flavonoids in experimental sepsis: A systematic review and meta-analysis.

Autor: de Oliveira Rodrigues Junior E; Department of Physiology, Federal University of Sergipe, Sao Cristovao, Sergipe, Brazil., de Santana IR; Department of Physiology, Federal University of Sergipe, Sao Cristovao, Sergipe, Brazil.; Health Sciences Graduate Program, Federal University of Sergipe, Hospital Universitário, Aracaju, Sergipe, Brazil., Durço AO; Health Sciences Graduate Program, Federal University of Sergipe, Hospital Universitário, Aracaju, Sergipe, Brazil., Conceição LSR; Department of Physical Therapy, Federal University of Sergipe, Hospital Universitário, Aracaju, Sergipe, Brazil., Barreto AS; Health Sciences Graduate Program, Federal University of Sergipe, Hospital Universitário, Aracaju, Sergipe, Brazil.; Department of Health Education, Federal University of Sergipe, Lagarto, Sergipe, Brazil., Menezes IAC; Hospital de Clínicas, Federal University of Paraná, Curitiba, Paraná, Brazil., Roman-Campos D; Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil., Dos Santos MRV; Department of Physiology, Federal University of Sergipe, Sao Cristovao, Sergipe, Brazil.; Health Sciences Graduate Program, Federal University of Sergipe, Hospital Universitário, Aracaju, Sergipe, Brazil.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2023 Jun; Vol. 37 (6), pp. 2531-2551. Date of Electronic Publication: 2023 Apr 28.
DOI: 10.1002/ptr.7846
Abstrakt: Sepsis is a host's dysregulated immune response to an infection associated with systemic inflammation and excessive oxidative stress, which can cause multiple organ failure and death. The literature suggests that flavonoids, a broad class of secondary plant metabolites, have numerous biological activities which can be valuable in the treatment of sepsis. This study aimed to review the effects of flavonoids on experimental sepsis, focusing mainly on survival rate, and also summarizing information on its mechanisms of action. We searched in the main databases up to November 2022 using relevant keywords, and data were extracted and analyzed qualitatively and quantitatively. Thirty-two articles met the study criteria for review and 29 for meta-analysis. Overall, 30 different flavonoids were used in the studies. The flavonoids were able to strongly inhibit inflammatory response by reducing the levels of important pro-inflammatory mediators, for example, tumor necrosis factor-alpha and interleukin-1β, oxidative stress, and showed antibacterial and anti-apoptotic actions. The meta-analysis found an increase of 50% in survival rate of the animals treated with flavonoids. They appear to act as multi-target drugs and may be an excellent therapeutic alternative to reduce a number of the complications caused by sepsis, and consequently, to improve survival rate.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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