Signatures of HIV and Major Depressive Disorder in the Plasma Microbiome.

Autor:	Taylor BC; Biomedical Sciences Graduate Program, University of California San Diego, San Diego, CA 92093, USA., Sheikh Andalibi M; Departments of Neurosciences and Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, CA 92093, USA., Wandro S; Center for Microbiome Innovation, University of California San Diego, San Diego, CA 92093, USA., Weldon KC; Center for Microbiome Innovation, University of California San Diego, San Diego, CA 92093, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA 92093, USA., Sepich-Poore GD; Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA., Carpenter CS; Center for Microbiome Innovation, University of California San Diego, San Diego, CA 92093, USA., Fraraccio S; Center for Microbiome Innovation, University of California San Diego, San Diego, CA 92093, USA., Franklin D; Department of Psychiatry, School of Medicine, University of California, San Diego, CA 92093, USA., Iudicello JE; Department of Psychiatry, School of Medicine, University of California, San Diego, CA 92093, USA., Letendre S; Departments of Medicine and Psychiatry, University of California San Diego, San Diego, CA 92093, USA., Gianella S; Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA 92093, USA., Grant I; Department of Psychiatry, School of Medicine, University of California, San Diego, CA 92093, USA., Ellis RJ; Departments of Neurosciences and Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, CA 92093, USA., Heaton RK; Department of Psychiatry, School of Medicine, University of California, San Diego, CA 92093, USA., Knight R; Center for Microbiome Innovation, University of California San Diego, San Diego, CA 92093, USA.; Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.; Department of Pediatrics, School of Medicine, University of California San Diego, San Diego, CA 92093, USA.; Department of Computer Science and Engineering, University of California San Diego, San Diego, CA 92093, USA., Swafford AD; Center for Microbiome Innovation, University of California San Diego, San Diego, CA 92093, USA.
Jazyk:	angličtina
Zdroj:	Microorganisms [Microorganisms] 2023 Apr 14; Vol. 11 (4). Date of Electronic Publication: 2023 Apr 14.
DOI:	10.3390/microorganisms11041022
Abstrakt:	Inter-individual differences in the gut microbiome are linked to alterations in inflammation and blood-brain barrier permeability, which may increase the risk of depression in people with HIV (PWH). The microbiome profile of blood, which is considered by many to be typically sterile, remains largely unexplored. We aimed to characterize the blood plasma microbiome composition and assess its association with major depressive disorder (MDD) in PWH and people without HIV (PWoH). In this cross-sectional, observational cohort, we used shallow-shotgun metagenomic sequencing to characterize the plasma microbiome of 151 participants (84 PWH and 67 PWoH), all of whom underwent a comprehensive neuropsychiatric assessment. The microbial composition did not differ between PWH and PWoH or between participants with MDD and those without it. Using the songbird model, we computed the log ratio of the highest and lowest 30% of the ranked classes associated with HIV and MDD. We found that HIV infection and lifetime MDD were enriched in a set of differentially abundant inflammatory classes, such as Flavobacteria and Nitrospira. Our results suggest that the circulating plasma microbiome may increase the risk of MDD related to dysbiosis-induced inflammation in PWH. If confirmed, these findings may indicate new biological mechanisms that could be targeted to improve treatment of MDD in PWH.
Databáze:	MEDLINE
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