Association of Metabolomic Biomarkers with Sleeve Gastrectomy Weight Loss Outcomes.

Autor:	Miller WM; Department of Nutrition and Preventive Medicine, Corewell Health William Beaumont University Hospital, 3601 W. 13 Mile Road, Royal Oak, MI 48073, USA.; Oakland University William Beaumont School of Medicine, 586 Pioneer Dr, Rochester, MI 48309, USA., Ziegler KM; Department of Nutrition and Preventive Medicine, Corewell Health William Beaumont University Hospital, 3601 W. 13 Mile Road, Royal Oak, MI 48073, USA.; Oakland University William Beaumont School of Medicine, 586 Pioneer Dr, Rochester, MI 48309, USA., Yilmaz A; Beaumont Research Institute, 3811 W 13 Mile Rd, Royal Oak, MI 48073, USA., Saiyed N; Beaumont Research Institute, 3811 W 13 Mile Rd, Royal Oak, MI 48073, USA., Ustun I; DePaul University Jarvis College of Computing and Digital Media, 243 S Wabash Ave, Chicago, IL 60604, USA., Akyol S; NX Prenatal Inc. Laboratory, 4800 Fournace Place, Suite BW28, Bellaire, TX 77401, USA., Idler J; Allegheny Health Network, West Penn Hospital, 4815 Liberty Ave, Suite GR50, Pittsburgh, PA 15224, USA.; Drexel University College of Medicine, 2900 W Queen Ln, Philadelphia, PA 19129, USA., Sims MD; Department of Nutrition and Preventive Medicine, Corewell Health William Beaumont University Hospital, 3601 W. 13 Mile Road, Royal Oak, MI 48073, USA.; Beaumont Research Institute, 3811 W 13 Mile Rd, Royal Oak, MI 48073, USA., Maddens ME; Department of Nutrition and Preventive Medicine, Corewell Health William Beaumont University Hospital, 3601 W. 13 Mile Road, Royal Oak, MI 48073, USA.; Oakland University William Beaumont School of Medicine, 586 Pioneer Dr, Rochester, MI 48309, USA., Graham SF; Department of Nutrition and Preventive Medicine, Corewell Health William Beaumont University Hospital, 3601 W. 13 Mile Road, Royal Oak, MI 48073, USA.; Beaumont Research Institute, 3811 W 13 Mile Rd, Royal Oak, MI 48073, USA.
Jazyk:	angličtina
Zdroj:	Metabolites [Metabolites] 2023 Mar 31; Vol. 13 (4). Date of Electronic Publication: 2023 Mar 31.
DOI:	10.3390/metabo13040506
Abstrakt:	This prospective observational study aimed to evaluate the association of metabolomic alterations with weight loss outcomes following sleeve gastrectomy (SG). We evaluated the metabolomic profile of serum and feces prior to SG and three months post-SG, along with weight loss outcomes in 45 adults with obesity. The percent total weight loss for the highest versus the lowest weight loss tertiles (T3 vs. T1) was 17.0 ± 1.3% and 11.1 ± 0.8%, p < 0.001. Serum metabolite alterations specific to T3 at three months included a decrease in methionine sulfoxide concentration as well as alterations to tryptophan and methionine metabolism ( p < 0.03). Fecal metabolite changes specific to T3 included a decrease in taurine concentration and perturbations to arachidonic acid metabolism, and taurine and hypotaurine metabolism ( p < 0.002). Preoperative metabolites were found to be highly predictive of weight loss outcomes in machine learning algorithms, with an average area under the curve of 94.6% for serum and 93.4% for feces. This comprehensive metabolomics analysis of weight loss outcome differences post-SG highlights specific metabolic alterations as well as machine learning algorithms predictive of weight loss. These findings could contribute to the development of novel therapeutic targets to enhance weight loss outcomes after SG.
Databáze:	MEDLINE
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