The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel Disease.

Autor: Liyanage NM; Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea., Nagahawatta DP; Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea., Jayawardena TU; Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, QC G8Z 4M3, Canada., Jeon YJ; Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.; Marine Science Institute, Jeju National University, Jeju 63333, Republic of Korea.
Jazyk: angličtina
Zdroj: Life (Basel, Switzerland) [Life (Basel)] 2023 Apr 16; Vol. 13 (4). Date of Electronic Publication: 2023 Apr 16.
DOI: 10.3390/life13041026
Abstrakt: Inflammatory bowel disease (IBD) is a prominent global public health issue. Anti-inflammatory medications, immunosuppressants, and biological therapies are currently used as treatments. However, they are often unsuccessful and have negative consequences on human health. Thus, there is a tremendous demand for using natural substances, such as seaweed polysaccharides, to treat IBD's main pathologic treatment targets. The cell walls of marine algae are rich in sulfated polysaccharides, including carrageenan in red algae, ulvan in green algae, and fucoidan in brown algae. These are effective candidates for drug development and functional nutrition products. Algal polysaccharides treat IBD through therapeutic targets, including inflammatory cytokines, adhesion molecules, intestinal epithelial cells, and intestinal microflora. This study aimed to systematically review the potential therapeutic effects of algal polysaccharides on IBD while providing the theoretical basis for a nutritional preventive mechanism for IBD and the restoration of intestinal health. The results suggest that algal polysaccharides have significant potential in complementary IBD therapy and further research is needed for fully understanding their mechanisms of action and potential clinical applications.
Databáze: MEDLINE
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