| Autor: |
Isac R; Pediatric Department, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.; Emergency Hospital for Children 'Louis Turcanu', Iosif Nemoianu Street, No. 2, 300011 Timișoara, Romania., Costa R; Emergency Hospital for Children 'Louis Turcanu', Iosif Nemoianu Street, No. 2, 300011 Timișoara, Romania., Frandes M; Department of Functional Sciences, Discipline of Biostatistics and Medical Informatics, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania., Lazureanu VE; Department of Infectious Diseases, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania., Stroescu RF; Pediatric Department, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.; Emergency Hospital for Children 'Louis Turcanu', Iosif Nemoianu Street, No. 2, 300011 Timișoara, Romania., Steflea RM; Pediatric Department, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.; Emergency Hospital for Children 'Louis Turcanu', Iosif Nemoianu Street, No. 2, 300011 Timișoara, Romania., Bagiu IC; Department of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania., Horhat FG; Department of Microbiology, Multidisciplinary Research Center on Antimicrobial Resistance, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania., Chicin GN; Department of Epidemiology, Infectious Diseases, Preventive Medicine and Epidemiology, 'VASILE GOLDIŞ' Western University of Arad, Revolutiei Boulevard, No. 94-96, 310025 Arad, Romania.; National Public Health Institute, 'Victor Babes' Boulevard, No. 16, 300226 Timișoara, Romania., Roberta AC; Department of Physiology and Pathophysiology, Medicine Faculty, 'VASILE GOLDIŞ' Western University of Arad, Revolutiei Boulevard, No. 94-96, 310025 Arad, Romania., Cornelia PA; MedLife HyperClinic, Eroilor de la Tisa Boulevard, No. 28, 300551 Timișoara, Romania., Doros G; Pediatric Department, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.; Emergency Hospital for Children 'Louis Turcanu', Iosif Nemoianu Street, No. 2, 300011 Timișoara, Romania., Gafencu M; Pediatric Department, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.; Emergency Hospital for Children 'Louis Turcanu', Iosif Nemoianu Street, No. 2, 300011 Timișoara, Romania. |
| Abstrakt: |
Human immunodeficiency virus (HIV) is a lentivirus that is transmissible through blood and other body fluids. During the late 1980s and early 1990s, an estimated 10,000 Romanian children were infected with HIV-1 subtype F nosocomially through contaminated needles and untested blood transfusions. Romania was a special case in the global acquired immunodeficiency syndrome (AIDS) pandemic, displaying the largest population of HIV-infected children by parental transmission between 1987-1990. In total, 205 HIV-infected patients from the western part of Romania were analyzed in this retrospective study. Over 70% of them had experienced horizontal transmission from an unknown source, while vertical transmission was identified in only five cases. Most patients had a moderate to severe clinical manifestation of HIV infection, 77.56% had undergone antiretroviral (ARV) treatment, most of them (71.21%) had experienced no adverse reactions and many of those with HIV (90.73%) had an undetectable viral load. Renal impairment was detected in one third of patients (34.63%). Patients born before 1990, male patients, patients diagnosed with HIV before the age of 10, and those undernourished or with renal impairment had a shorter average survival time than the group born after 1990, female patients, patients receiving ARV treatment, patients with a normal body mass index (BMI) and those without renal impairment. Periodical monitoring of the estimated glomerular filtration rate (eGFR) level, as well as the detection of protein excretion, should be taken into consideration worldwide when monitoring HIV-positive patients; this in order to detect even asymptomatic chronic kidney disease (CKD), and to manage these patients and prolong their lives. |
