Molecular and Sociodemographic Colorectal Cancer Disparities in Latinos Living in Puerto Rico.

Autor:	Perez-Mayoral J; NCI Center for Cancer Genomics, Bethesda, MD 20892, USA., Gonzalez-Pons M; University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00936, USA., Centeno-Girona H; University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00936, USA., Montes-Rodríguez IM; University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00936, USA., Soto-Salgado M; University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00936, USA., Suárez B; University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00936, USA., Rodríguez N; School of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA., Colón G; School of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA., Sevilla J; School of Medicine, Universidad Central del Caribe, Bayamon, PR 00956, USA., Jorge D; School of Medicine, Ponce Health Sciences University, Ponce, PR 00716, USA., Llor X; Department of Internal Medicine and Digestive Diseases, School of Medicine, Yale University, New Haven, CT 06520, USA., Xicola RM; Department of Internal Medicine and Digestive Diseases, School of Medicine, Yale University, New Haven, CT 06520, USA., Toro DH; VA Caribbean Healthcare System, San Juan, PR 00921, USA., Tous-López L; Ashford Presbyterian Community Hospital, San Juan, PR 00907, USA., Torres-Torres M; Ashford Presbyterian Community Hospital, San Juan, PR 00907, USA., Reyes JS; Ashford Presbyterian Community Hospital, San Juan, PR 00907, USA., López-Acevedo N; Ashford Presbyterian Community Hospital, San Juan, PR 00907, USA., Goel A; Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA., Rodríguez-Quilichini S; Department of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR 00935, USA., Cruz-Correa M; University of Puerto Rico Comprehensive Cancer Center, San Juan, PR 00936, USA.; Department of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR 00935, USA.
Jazyk:	angličtina
Zdroj:	Genes [Genes (Basel)] 2023 Apr 11; Vol. 14 (4). Date of Electronic Publication: 2023 Apr 11.
DOI:	10.3390/genes14040894
Abstrakt:	Background: The incidence of sporadic colorectal cancer (CRC) among individuals <50 years (early-onset CRC) has been increasing in the United States (U.S.) and Puerto Rico. CRC is currently the leading cause of cancer death among Hispanic men and women living in Puerto Rico (PRH). The objective of this study was to characterize the molecular markers and clinicopathologic features of colorectal tumors from PRH to better understand the molecular pathways leading to CRC in this Hispanic subpopulation. Methods: Microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and KRAS and BRAF mutation status were analyzed. Sociodemographic and clinicopathological characteristics were evaluated using Chi-squared and Fisher's exact tests. Results: Of the 718 tumors analyzed, 34.2% ( n = 245) were early-onset CRC, and 51.7% were males. Among the tumors with molecular data available ( n = 192), 3.2% had MSI, 9.7% had BRAF , and 31.9% had KRAS mutations. The most common KRAS mutations observed were G12D (26.6%) and G13D (20.0%); G12C was present in 4.4% of tumors. A higher percentage of Amerindian admixture was significantly associated with early-onset CRC. Conclusions: The differences observed in the prevalence of the molecular markers among PRH tumors compared to other racial/ethnic groups suggest a distinct molecular carcinogenic pathway among Hispanics. Additional studies are warranted.
Databáze:	MEDLINE
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