Effects of antioxidant supplementation on bone mineral density, bone mineral content and bone structure in healthy men during 60 days of 6° head-down tilt bed rest: Results from a randomised controlled trial.

Autor: Austermann K; Institute of Nutrition and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany., Baecker N; IU International University of Applied Sciences, Bad Reichenhall, Erfurt, Germany., Zwart SR; Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas, USA., Fimmers R; Department of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany., Stehle P; Institute of Nutrition and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany., Smith SM; Human Health and Performance Directorate, NASA Lyndon B. Johnson Space Center, Houston, Texas, USA., Heer M; Institute of Nutrition and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany.; IU International University of Applied Sciences, Bad Reichenhall, Erfurt, Germany.
Jazyk: angličtina
Zdroj: Nutrition bulletin [Nutr Bull] 2023 Jun; Vol. 48 (2), pp. 256-266. Date of Electronic Publication: 2023 Apr 27.
DOI: 10.1111/nbu.12619
Abstrakt: Dietary countermeasures to mitigate detrimental spaceflight-induced effects on bone health would alleviate the requirements and the consequences imposed by other types of countermeasures for this risk. We hypothesised that antioxidant supplementation during 60 days of 6° head-down tilt bed rest (HDBR), an analogue of spaceflight, would have a protective effect on bone mineral density (BMD), content (BMC) and bone structure parameters. An exploratory, randomised, controlled, single-blind intervention trial was conducted in a parallel design with 20 healthy male volunteers (age 34 ± 8 y, weight 74 ± 6 kg). The study included 14 days of baseline data collection (BDC) before bed rest, followed by 60 days of HDBR and a 14-day recovery period. Ten subjects in the antioxidant group received a supplement (741 mg/d polyphenols, 2.1 g/d omega-3 fatty acids, 168 mg/d vitamin E and 80 μg/d selenium) daily. Ten subjects in the control group received no supplement. The diet was consistent with dietary reference intakes, individually tailored based on the subject's bodyweight and strictly controlled. We measured whole-body, lumbar spine and femur BMD and BMC, as well as BMD of the cortical and trabecular compartments of the distal radius and tibia, and cortical and trabecular thickness during BDC, HDBR and recovery. Data were analysed using linear mixed models. The supplementation of an antioxidant cocktail did not mitigate the deteriorating effects of HDBR on BMD, BMC and bone structure parameters. Our findings do not support a recommendation for antioxidant supplementation for astronauts.
(© 2023 The Authors. Nutrition Bulletin published by John Wiley & Sons Ltd on behalf of British Nutrition Foundation.)
Databáze: MEDLINE
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