Microneedle and Polymeric Films: Delivery of Proteins, Peptides and Nucleic Acids.
| Autor: | Wu Y; School of Pharmacy, Queen's University Belfast, Belfast, UK., Hutton ARJ; School of Pharmacy, Queen's University Belfast, Belfast, UK., Pandya AK; School of Pharmacy, Queen's University Belfast, Belfast, UK.; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parekh Marg Matunga, Mumbai, Maharashtra, India., Patravale VB; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parekh Marg Matunga, Mumbai, Maharashtra, India., Donnelly RF; School of Pharmacy, Queen's University Belfast, Belfast, UK. R.Donnelly@qub.ac.uk. |
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| Jazyk: | angličtina |
| Zdroj: | Handbook of experimental pharmacology [Handb Exp Pharmacol] 2024; Vol. 284, pp. 93-111. |
| DOI: | 10.1007/164_2023_653 |
| Abstrakt: | In the last 20 years, protein, peptide and nucleic acid-based therapies have become the fastest growing sector in the pharmaceutical industry and play a vital role in disease therapy. However, the intrinsic sensitivity and large molecular sizes of biotherapeutics limit the available routes of administration. Currently, the main administration routes of biomacromolecules, such as parenteral, oral, pulmonary, nasal, rectal and buccal routes, each have their limitations. Several non-invasive strategies have been proposed to overcome these challenges. Researchers were particularly interested in microneedles (MNs) and polymeric films because of their less invasiveness, convenience and greater potential to preserve the bioactivity of biotherapeutics. By facilitating with MNs and polymeric films, biomacromolecules could provide significant benefits to patients suffering from various diseases such as cancer, diabetes, infectious and ocular diseases. However, before these devices can be used on patients, how to upscale MN manufacture in a cost-effective and timely manner, as well as the long-term safety of MN and polymeric film applications necessitates further investigation. (© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.) |
| Databáze: | MEDLINE |
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