Resurgence of Omicron BA.2 in SARS-CoV-2 infection-naive Hong Kong.

Autor: Xie R; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Edwards KM; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Adam DC; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Leung KSM; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Tsang TK; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Gurung S; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Xiong W; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Wei X; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Ng DYM; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Liu GYZ; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Krishnan P; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Chang LDJ; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Cheng SMS; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Gu H; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Siu GKH; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR, China., Wu JT; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Laboratory of Data Discovery for Health, Hong Kong Science and Technology Park, New Territories, Hong Kong SAR, China., Leung GM; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Laboratory of Data Discovery for Health, Hong Kong Science and Technology Park, New Territories, Hong Kong SAR, China., Peiris M; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Centre for Immunology & Infection, Hong Kong Science and Technology Park, New Territories, Hong Kong SAR, China., Cowling BJ; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Laboratory of Data Discovery for Health, Hong Kong Science and Technology Park, New Territories, Hong Kong SAR, China., Poon LLM; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.; Centre for Immunology & Infection, Hong Kong Science and Technology Park, New Territories, Hong Kong SAR, China., Dhanasekaran V; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. veej@hku.hk.; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. veej@hku.hk.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Apr 27; Vol. 14 (1), pp. 2422. Date of Electronic Publication: 2023 Apr 27.
DOI: 10.1038/s41467-023-38201-5
Abstrakt: Hong Kong experienced a surge of Omicron BA.2 infections in early 2022, resulting in one of the highest per-capita death rates of COVID-19. The outbreak occurred in a dense population with low immunity towards natural SARS-CoV-2 infection, high vaccine hesitancy in vulnerable populations, comprehensive disease surveillance and the capacity for stringent public health and social measures (PHSMs). By analyzing genome sequences and epidemiological data, we reconstructed the epidemic trajectory of BA.2 wave and found that the initial BA.2 community transmission emerged from cross-infection within hotel quarantine. The rapid implementation of PHSMs suppressed early epidemic growth but the effective reproduction number (R e ) increased again during the Spring festival in early February and remained around 1 until early April. Independent estimates of point prevalence and incidence using phylodynamics also showed extensive superspreading at this time, which likely contributed to the rapid expansion of the epidemic. Discordant inferences based on genomic and epidemiological data underscore the need for research to improve near real-time epidemic growth estimates by combining multiple disparate data sources to better inform outbreak response policy.
(© 2023. The Author(s).)
Databáze: MEDLINE
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