Association of KIR Genes Polymorphism and its HLA Ligands in Diffuse Large B-cell Lymphoma.

Autor: Daniela Maira C; Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. Electronic address: danielamcardozo@hc.unicamp.br., Amanda Vansan M; Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Fernando G; Centro de Atenção Integral a Saúde da Mulher, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Silvia M; Laboratório de Imunogenética, Hemocentro, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Sofia L; Laboratório de Imunogenética, Hemocentro, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Márcia D; Hemocentro, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Francisco José Penteado A; Hemocentro, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Jeane Eliete Laguila V; Laboratório de Imunogenética, Universidade Estadual de Maringá, Campinas, São Paulo, Brazil., Cármino Antonio S; Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Clinical lymphoma, myeloma & leukemia [Clin Lymphoma Myeloma Leuk] 2023 Jun; Vol. 23 (6), pp. 438-445. Date of Electronic Publication: 2023 Mar 09.
DOI: 10.1016/j.clml.2023.03.001
Abstrakt: Introduction: Non-Hodgkin lymphoma (NHL) is a heterogeneous disease, with each subtype associated with different risk factors. Within this group, diffuse large B-cell lymphoma (DLBCL) can be highlighted, the most common type of NHL.NK cells are key components of the innate immune response and may play an important antitumor role.
Objective: The objective of the present work was to determine the polymorphism of KIR genes in Brazilian patients with DLBCL.
Materials and Methods: Furthermore, we evaluated the association between the polymorphism of these genes and their ligands with the clinical course of the disease. For the study, 112 patients with DLBCL and 222 voluntary blood and bone marrow donors. The genetic material of these samples were extracted for KIR and HLA typing, determination of HLA ligands, determination of the KIR haplotype and search for the deletion of 22 bp in the KIR2DS4 gene. KIR genotype distributions were made by direct counting using 2 × 2 contingency tables using Fisher's exact test. The magnitude of the association was measured by odds ratio (OR) and 95% confidence interval. P values <.05 were considered significant. Overall survival and progression-free survival were assessed with a Kaplan-Meier estimator.
Results: In the present study, an association of HLA-Bw4 and HLA-Bw480I ligand was found with more advanced stages of the disease. Also, an association of the KIR2DL3 gene with a better response to treatment was found.
Conclusion: With this, we can conclude that the polymorphism of KIR genes and the association with HLA ligands can influence the prognosis of DLBCL, as well as the response to treatment was found. With this, we can conclude that the polymorphism of KIR genes and the association with HLA ligands can influence the prognosis of DLBCL, as well as the response to treatment.Non-Hodgkin lymphoma (NHL) is a heterogeneous disease, with each subtype associated with different risk factors. Within this group, diffuse large B-cell lymphoma (DLBCL) can be highlighted, the most common type of NHL.NK cells are key components of the innate immune response and may play an important antitumor role. The objective of the present work was to determine the polymorphism of KIR genes in Brazilian patients with DLBCL. Furthermore, we evaluated the association between the polymorphism of these genes and their ligands with the clinical course of the disease. For the study, 112 patients with DLBCL and 222 voluntary blood and bone marrow donors. The genetic material of these samples were extracted for KIR and HLA typing, determination of HLA ligands, determination of the KIR haplotype and search for the deletion of 22 bp in the KIR2DS4 gene. KIR genotype distributions were made by direct counting using 2 × 2 contingency tables using Fisher's exact test. The magnitude of the association was measured by odds ratio (OR) and 95% confidence interval. P values <.05 were considered significant. Overall survival and progression-free survival were assessed with a Kaplan-Meier estimator. In the present study, an association of HLA-Bw4 and HLA-Bw480I ligand was found with more advanced stages of the disease. Also, an association of the KIR2DL3 gene with a better response to treatment was found. With this, we can conclude that the polymorphism of KIR genes and the association with HLA ligands can influence the prognosis of DLBCL, as well as the response to treatment was found. With this, we can conclude that the polymorphism of KIR genes and the association with HLA ligands can influence the prognosis of DLBCL, as well as the response to treatment.
Competing Interests: Disclosure The authors declare that there is no conflict of interest.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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