Mpox outbreak among men who have sex with men in Amsterdam and Rotterdam, the Netherlands: no evidence for undetected transmission prior to May 2022, a retrospective study.

Autor:	de Vries HJ; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.; Department of Dermatology, Amsterdam UMC, location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunology, Infectious Diseases, Amsterdam, the Netherlands.; Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands., Götz HM; Department of Public Health, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, the Netherlands.; Department of Public Health, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Bruisten S; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunology, Infectious Diseases, Amsterdam, the Netherlands., van der Eijk AA; Department of Viroscience, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Prins M; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunology, Infectious Diseases, Amsterdam, the Netherlands.; Amsterdam UMC location University of Amsterdam, Department of Infectious Diseases, Meibergdreef 9, Amsterdam, the Netherlands., Oude Munnink BB; Department of Viroscience, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Welkers MR; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.; Amsterdam UMC location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Meibergdreef 9, Amsterdam, the Netherlands., Jonges M; Amsterdam UMC location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Meibergdreef 9, Amsterdam, the Netherlands., Molenkamp R; Department of Viroscience, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Westerhuis BM; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.; Amsterdam UMC location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Meibergdreef 9, Amsterdam, the Netherlands., Schuele L; Department of Viroscience, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Stam A; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.; Amsterdam UMC location AMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Meibergdreef 9, Amsterdam, the Netherlands., Boter M; Department of Viroscience, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Hoornenborg E; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Infection and Immunology, Infectious Diseases, Amsterdam, the Netherlands., Mulders D; Department of Viroscience, Erasmus MC University Medical Center, Rotterdam, the Netherlands., van den Lubben M; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands., Koopmans M; Department of Viroscience, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Jazyk:	angličtina
Zdroj:	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2023 Apr; Vol. 28 (17).
DOI:	10.2807/1560-7917.ES.2023.28.17.2200869
Abstrakt:	Since May 2022, over 21,000 mpox cases have been reported from 29 EU/EEA countries, predominantly among men who have sex with men (MSM). The Netherlands was the fourth most affected country in Europe, with more than 1,200 cases and a crude notification rate of 70.7 per million population. The first national case was reported on 10 May, yet potential prior transmission remains unknown. Insight into prolonged undetected transmission can help to understand the current outbreak dynamics and aid future public health interventions. We performed a retrospective study and phylogenetic analysis to elucidate whether undetected transmission of human mpox virus (hMPXV) occurred before the first reported cases in Amsterdam and Rotterdam. In 401 anorectal and ulcer samples from visitors to centres for sexual health in Amsterdam or Rotterdam dating back to 14 February 2022, we identified two new cases, the earliest from 6 May. This coincides with the first cases reported in the United Kingdom, Spain and Portugal. We found no evidence of widespread hMPXV transmission in Dutch sexual networks of MSM before May 2022. Likely, the mpox outbreak expanded across Europe within a short period in the spring of 2022 through an international highly intertwined network of sexually active MSM.
Databáze:	MEDLINE
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