A neglected among the neglected: a review of cutaneous leishmaniasis in Guatemala.

Autor:	Lopez Y; Center for Health Studies, Universidad del Valle de Guatemala, 18 Avenida 11-95, Guatemala City 01015, Guatemala.; Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Arana B; Center for Health Studies, Universidad del Valle de Guatemala, 18 Avenida 11-95, Guatemala City 01015, Guatemala., Rizzo N; Center for Health Studies, Universidad del Valle de Guatemala, 18 Avenida 11-95, Guatemala City 01015, Guatemala., Duran E; Ministry of Health and Social Assistance, 3-45, 6a Avenida 3, Guatemala City 01011, Guatemala., Acosta-Serrano Á; Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Mendizabal-Cabrera R; Center for Health Studies, Universidad del Valle de Guatemala, 18 Avenida 11-95, Guatemala City 01015, Guatemala.
Jazyk:	angličtina
Zdroj:	Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2023 Sep 01; Vol. 117 (9), pp. 609-616.
DOI:	10.1093/trstmh/trad024
Abstrakt:	Cutaneous leishmaniasis (CL) is a parasitic vector-borne disease affecting mostly low- and middle-income countries. CL is endemic in Guatemala, where an increase in the number of cases and incidence and a changing disease distribution in the past decade have been reported. Important research was conducted in Guatemala in the 1980s and 1990s to understand the epidemiology of CL and two Leishmania species were identified as the aetiologic agents. Several species of sand flies have been reported, five of which are naturally infected with Leishmania. Clinical trials conducted in the country evaluated different treatments against the disease and provided solid evidence for CL control strategies that are applicable worldwide. More recently, in the 2000s and 2010s, qualitative surveys were conducted to understand community perceptions of the disease and to highlight the challenges and enablers for disease control. However, limited recent data have been generated regarding the current CL situation in Guatemala, and key information necessary for effective disease control, such as incrimination of vectors and reservoirs, is still lacking. This review describes the current state of knowledge of CL in Guatemala, including the main parasite and sand fly species, disease reservoirs, diagnosis and control, as well as the perceptions of communities in endemic regions. (© The Author(s) 2023. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.)
Databáze:	MEDLINE
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