Clinical Impact of Proton Beam Therapy for Postoperative Lymph Node Oligorecurrence of Esophageal Cancer.

Autor:	Hiroshima Y; Department of Radiation Oncology, Proton Medical Research Center, Faculty of Medicine, University of Tsukuba Hospital, Tsukuba, Japan; hiroshima@pmrc.tsukuba.ac.jp.; Department of Radiation Oncology, Ibaraki Prefectural Central Hospital, Kasama, Japan., Ishikawa H; Department of Radiation Oncology, Proton Medical Research Center, Faculty of Medicine, University of Tsukuba Hospital, Tsukuba, Japan.; QST hospital, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan., Sumiya T; Department of Radiation Oncology, Proton Medical Research Center, Faculty of Medicine, University of Tsukuba Hospital, Tsukuba, Japan., Murakami M; Department of Radiation Oncology, Proton Medical Research Center, Faculty of Medicine, University of Tsukuba Hospital, Tsukuba, Japan., Nakamura M; Department of Radiation Oncology, Proton Medical Research Center, Faculty of Medicine, University of Tsukuba Hospital, Tsukuba, Japan., Ishida T; Department of Radiation Oncology, Proton Medical Research Center, Faculty of Medicine, University of Tsukuba Hospital, Tsukuba, Japan., Ogawa K; Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan., Hisakura K; Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan., Mizumoto M; Department of Radiation Oncology, Proton Medical Research Center, Faculty of Medicine, University of Tsukuba Hospital, Tsukuba, Japan., Oda T; Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan., Okumura T; Department of Radiation Oncology, Proton Medical Research Center, Faculty of Medicine, University of Tsukuba Hospital, Tsukuba, Japan.; Department of Radiation Oncology, Ibaraki Prefectural Central Hospital, Kasama, Japan., Sakurai H; Department of Radiation Oncology, Proton Medical Research Center, Faculty of Medicine, University of Tsukuba Hospital, Tsukuba, Japan.
Jazyk:	angličtina
Zdroj:	In vivo (Athens, Greece) [In Vivo] 2023 May-Jun; Vol. 37 (3), pp. 1253-1259.
DOI:	10.21873/invivo.13202
Abstrakt:	Background/aim: Radiotherapy is a salvage therapy type for postoperative recurrence of esophageal cancer. Compared to conventional photon-based radiotherapy, proton beam therapy can reduce the irradiated dose to the surrounding organs, facilitating the management of patients who are unfit for radiotherapy. In this study, the outcomes and toxicity of proton beam therapy for postoperative lymph node oligorecurrence of esophageal cancer were investigated. Patients and Methods: We retrospectively evaluated the clinical outcomes and toxicity of 13 sites in 11 patients treated with proton beam therapy for postoperative lymph node oligorecurrence of esophageal cancer. In total, eight men and three women with a median age of 68 years (range=46-83 years) were included. Results: The median follow-up period was 20.2 months. During the follow-up period, four patients died of esophageal cancer. Eight of the 11 patients developed recurrence; of these, seven patients had recurrence outside the irradiated field, and one had recurrence inside and outside the irradiated field. The 2-year overall survival, progression-free survival, and local control rates were 48.0%, 27.3%, and 84.6%, respectively. The median survival time was 22.4 months. There were no severe acute or late adverse events. Conclusion: Proton beam therapy could be a safe and effective treatment method for postoperative lymph node oligorecurrence of esophageal cancer. It may be beneficial even in cases where conventional photon-based radiotherapy is difficult to administer in combination with increased doses or with chemotherapy. (Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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