Autor: |
Mohammad CA; Periodontics Department, College of Dentistry, Hawler Medical University, Erbil 44001, Iraq., Mirza BA; Periodontics Department, College of Dentistry, Hawler Medical University, Erbil 44001, Iraq., Mahmood ZS; Periodontics Department, College of Dentistry, Hawler Medical University, Erbil 44001, Iraq., Zardawi FM; Dean of Faculty of Dentistry, Qaiwan International University, Sulaimani 00964, Iraq.; Department of Periodontics, College of Dentistry, University of Sulaimani, Sulaymaniyah 46001, Iraq. |
Jazyk: |
angličtina |
Zdroj: |
Gels (Basel, Switzerland) [Gels] 2023 Apr 12; Vol. 9 (4). Date of Electronic Publication: 2023 Apr 12. |
DOI: |
10.3390/gels9040325 |
Abstrakt: |
Hyaluronic acid in its various forms shows bacteriostatic, fungistatic, anti-inflammatory, anti-edematous, osteoinductive, and pro-angiogenetic properties. This study aimed to evaluate the effect of subgingival delivery of 0.8% hyaluronic acid (HA) gel on clinical periodontal parameters, pro-inflammatory cytokines (IL-1 beta and TNF-alpha) and biochemical markers of inflammation (C-reactive protein (CRP) and alkaline phosphatase (ALP) enzymes) in patients with periodontitis. Seventy-five patients with chronic periodontitis were divided randomly into three groups (25 in each group): group I received scaling and surface root debridement (SRD) + HA gel; group II received SRD + chlorhexidine gel; and group III received surface root debridement alone. Clinical periodontal parameter measurements and blood samples were collected to estimate pro-inflammatory and biochemical parameters at the baseline before therapy and after two months of therapy. The results show that HA gel has a significant effect on the reduction in clinical periodontal parameters (PI, GI, BOP, PPD, and CAL), IL-1 beta, TNF-alpha, CRP, and ALP after 2 months of therapy as compared to the baseline ( p < 0.05) with nonsignificant differences from the CHX group ( p > 0.05), except GI ( p < 0.05), and significant differences from the SRD group ( p < 0.05). Moreover, significant differences were found between the three groups regarding the mean improvements of GI, BOP, PPD, IL-1β, CRP, and ALP. It can be concluded that HA gel has a positive effect on clinical periodontal parameters and improvements in inflammatory mediators similar to chlorhexidine. Therefore, HA gel can be used as an adjuvant to SRD in the treatment of periodontitis. |
Databáze: |
MEDLINE |
Externí odkaz: |
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