Early-life environment and the risk of eczema at 2 years-Meta-analyses of six Finnish birth cohorts.

Autor: Lukkarinen M; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.; Department of Paediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland., Kirjavainen PV; Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Backman K; Kuopio Birth Cohort (KuBiCo), University of Eastern Finland, Kuopio, Finland.; Department of Paediatrics, Kuopio University Hospital, Kuopio, Finland., Gonzales-Inca C; Department of Geography and Geology, University of Turku, Turku, Finland., Hickman B; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Kallio S; FLORA: New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Karlsson H; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland., Karlsson L; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.; Department of Paediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Keski-Nisula L; Kuopio Birth Cohort (KuBiCo), University of Eastern Finland, Kuopio, Finland.; Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland., Korhonen LS; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.; Department of Paediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland., Korpela K; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Kuitunen M; FLORA: New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Kukkonen AK; FLORA: New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Käyhkö N; Department of Geography and Geology, University of Turku, Turku, Finland., Lagström H; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Lukkarinen H; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.; Department of Paediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland., Peltola V; Department of Paediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland., Pentti J; Department of Public Health, University of Turku, Turku, Finland.; Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Salonen A; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Savilahti E; FLORA: New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Tuoresmäki P; Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland., Täubel M; Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland., Vahtera J; Department of Public Health, University of Turku, Turku, Finland., de Vos WM; Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Pekkanen J; Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland.; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Karvonen AM; Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland.
Jazyk: angličtina
Zdroj: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology [Pediatr Allergy Immunol] 2023 Apr; Vol. 34 (4), pp. e13945.
DOI: 10.1111/pai.13945
Abstrakt: Background: Urban-related nature exposures are suggested to contribute to the rising prevalence of allergic diseases despite little supporting evidence. Our aim was to evaluate the impact of 12 land cover classes and two greenness indices around homes at birth on the development of doctor-diagnosed eczema by the age of 2 years, and the influence of birth season.
Methods: Data from 5085 children were obtained from six Finnish birth cohorts. Exposures were provided by the Coordination of Information on the Environment in three predefined grid sizes. Adjusted logistic regression was run in each cohort, and pooled effects across cohorts were estimated using fixed or random effect meta-analyses.
Results: In meta-analyses, neither greenness indices (NDVI or VCDI, 250 m × 250 m grid size) nor residential or industrial/commercial areas were associated with eczema by age of 2 years. Coniferous forest (adjusted odds ratio 1.19; 95% confidence interval 1.01-1.39 for the middle and 1.16; 0.98-1.28 for the highest vs. lowest tertile) and mixed forest (1.21; 1.02-1.42 middle vs. lowest tertile) were associated with elevated eczema risk. Higher coverage with agricultural areas tended to associate with elevated eczema risk (1.20; 0.98-1.48 vs. none). In contrast, transport infrastructure was inversely associated with eczema (0.77; 0.65-0.91 highest vs. lowest tertile).
Conclusion: Greenness around the home during early childhood does not seem to protect from eczema. In contrast, nearby coniferous and mixed forests may increase eczema risk, as well as being born in spring close to forest or high-green areas.
(© 2023 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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