Bioengineering approaches for nerve graft revascularization: Current concepts and future directions.

Autor: Pereira C; Department of Surgery, Division of Plastic and Reconstructive Surgery, University of California, Davis, Sacramento, California, USA., Lazar SV; Albany Medical College, Albany, New York, USA., Wang A; Department of Surgery, Center for Surgical Bioengineering, University of California, Davis, Sacramento, California, USA.; Shriners Hospitals for Children Northern California, Institute for Pediatric Regenerative Medicine, Sacramento, California, USA.; Department of Biomedical Engineering, University of California, Davis, Davis, California, USA.
Jazyk: angličtina
Zdroj: WIREs mechanisms of disease [WIREs Mech Dis] 2023 Jul-Aug; Vol. 15 (4), pp. e1609. Date of Electronic Publication: 2023 Apr 27.
DOI: 10.1002/wsbm.1609
Abstrakt: Peripheral nerve injury (PNI) is the most common neurological injury in civilian and military injuries, with over 360,000 PNI procedures performed in the US yearly. Segmental loss of nerve tissue results in a nerve gap precluding a tension-free primary repair, and in these cases, interpositional autologous or acellular nerve allografts are used to bridge the gap. Graft ischemia time is a critical factor in achieving satisfactory nerve regeneration. Rapid nerve graft revascularization is essential in order to sustain Schwann cell growth which in turn is crucial for axonal regeneration. Currently, nerve autografts are considered the gold standard for segmental nerve gaps but are associated with several disadvantages such as limited supply of expendable donor tissue, increased operative time, and donor site morbidity. Hence, readily available, off-the-shelf nerve allografts or scaffolds are being investigated since they provide advantages such as a virtually limitless sourcing, a wide variety of sizes to match recipient nerves, and no donor site morbidity. New, exciting advances in tissue engineering to augment revascularization of nerve allografts or conduits have been investigated. Strategies include pro-angiogenic mesenchymal stem cells, extracellular vesicles, functionalized scaffolds, bioactive peptides, and three-dimensional bioprinting. This article discusses these bioengineering advances and future strategies aimed at enhancing nerve graft and scaffold revascularization. This article is categorized under: Neurological Diseases > Biomedical Engineering Neurological Diseases > Molecular and Cellular Physiology.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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