Transcriptome analysis reveals a common adaptive transcriptional response of Candida glabrata to diverse environmental stresses.

Autor: Rai MN; Institute for Sustainability, Energy, and Environment, University of Illinois at Urbana Champaign, IL, USA. Electronic address: mnrai@illinois.edu., Rai R; Citrus Research and Education Center, University of Florida, FL, USA. Electronic address: rrai1@ufl.edu., Sethiya P; Centre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, Westmead, 2145, NSW, University of Sydney, Australia. Electronic address: poojasethiya24@gmail.com., Parsania C; Gene and Stem Cell Therapy Program Centenary Institute, Camperdown, NSW, 2050, Faculty of Medicine and Health, University of Sydney, Australia. Electronic address: chirag.parsania@gmail.com.
Jazyk: angličtina
Zdroj: Research in microbiology [Res Microbiol] 2023 Jun; Vol. 174 (5), pp. 104073. Date of Electronic Publication: 2023 Apr 24.
DOI: 10.1016/j.resmic.2023.104073
Abstrakt: Candida glabrata, an opportunistic fungal pathogen, causes superficial and life-threatening infections in humans. In the host microenvironment, C. glabrata encounters a variety of stresses, and its ability to cope with these stresses is crucial for its pathogenesis. To gain insights into how C. glabrata adapts to adverse environmental conditions, we examined its transcriptional landscape under heat, osmotic, cell wall, oxidative, and genotoxic stresses using RNA sequencing and reveal that C. glabrata displays a diverse transcriptional response involving ∼75% of its genome for adaptation to different environmental stresses. C. glabrata mounts a central common adaptation response wherein ∼25% of all genes (n = 1370) are regulated in a similar fashion at different environmental stresses. Elevated cellular translation and diminished mitochondrial activity-associated transcriptional signature characterize the common adaptation response. Transcriptional regulatory association networks of common adaptation response genes revealed a set of 29 transcription factors acting as potential activators and repressors of associated adaptive response genes. Overall, the current work delineates the adaptive responses of C. glabrata to diverse environmental stresses and reports the existence of a common adaptive transcriptional response upon prolonged exposure to environmental stresses.
Competing Interests: Competing interest declaration The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Published by Elsevier Masson SAS.)
Databáze: MEDLINE
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