Regional Growth Velocity and Incidence of Pancreatic Neuroendocrine Neoplasias in Multiple Endocrine Neoplasia Type 1.

Autor:	Kann PH, Scheunemann A; From the Centre for Endocrinology, Diabetology and Osteology, Endocrine Laboratory, Philipp's University and University Hospital, Marburg., Adelmeyer J; From the Centre for Endocrinology, Diabetology and Osteology, Endocrine Laboratory, Philipp's University and University Hospital, Marburg., Bergmann S; From the Centre for Endocrinology, Diabetology and Osteology, Endocrine Laboratory, Philipp's University and University Hospital, Marburg., Goebel JN; From the Centre for Endocrinology, Diabetology and Osteology, Endocrine Laboratory, Philipp's University and University Hospital, Marburg., Bartsch DK; Department of Visceral, Thoracic and Vascular Surgery, Philipp's University and University Hospital, Marburg, Germany., Holzer K; Department of Visceral, Thoracic and Vascular Surgery, Philipp's University and University Hospital, Marburg, Germany., Albers MB; Department of Visceral, Thoracic and Vascular Surgery, Philipp's University and University Hospital, Marburg, Germany., Manoharan J; Department of Visceral, Thoracic and Vascular Surgery, Philipp's University and University Hospital, Marburg, Germany., Scheunemann LM; From the Centre for Endocrinology, Diabetology and Osteology, Endocrine Laboratory, Philipp's University and University Hospital, Marburg.
Jazyk:	angličtina
Zdroj:	Pancreas [Pancreas] 2022 Nov-Dec 01; Vol. 51 (10), pp. 1327-1331.
DOI:	10.1097/MPA.0000000000002191
Abstrakt:	Objectives: Pancreatic neuroendocrine neoplasias (pNENs) in multiple endocrine neoplasia type 1 are predominantly found in the dorsal anlage. Whether their growth velocity and incidence might be related to their location in the pancreas has not been investigated yet. Methods: We studied 117 patients using endoscopic ultrasound. Results: Growth velocity could be calculated for 389 pNENs. Increase of largest tumor diameter (% per month) was 0.67 (standard deviation [SD], 2.04) in the pancreatic tail (n = 138), 1.12 (SD, 3.00) in the pancreatic body (n = 100), 0.58 (SD, 1.19) in the pancreatic head/uncinate process-dorsal anlage (n = 130), and 0.68 (SD, 0.77) in the pancreatic head/uncinate process-ventral anlage (n = 12). Comparing growth velocity of all pNENs in the dorsal (n = 368, 0.76 [SD, 2.13]) versus ventral anlage, no significant difference was detected. Annual tumor incidence rate was 0.21 in the pancreatic tail, 0.13 in the pancreatic body, 0.17 in the pancreatic head/uncinate process-dorsal anlage, 0.51 dorsal anlage together, and 0.02 in the pancreatic head/uncinate process-ventral anlage. Conclusions: Multiple endocrine neoplasia type 1 pNENs are unequally distributed between ventral (low prevalence and incidence) and dorsal anlage. However, there are no regional differences in growth behavior. Competing Interests: The authors declare no conflict of interest. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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