Prevalence and risk distribution of schistosomiasis among adults in Madagascar: a cross-sectional study.

Autor: Gruninger SK; Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research (DZIF), Hamburg-Borstel-Lübeck-Riems, Germany., Rasamoelina T; Centre d'Infectiologie Charles Mérieux (CICM), University of Antananarivo, 101, Antananarivo, Madagascar., Rakotoarivelo RA; Department of Infectious Diseases, University of Fianarantsoa Andrainjato, 301, Fianarantsoa, Madagascar., Razafindrakoto AR; Centre d'Infectiologie Charles Mérieux (CICM), University of Antananarivo, 101, Antananarivo, Madagascar., Rasolojaona ZT; Centre d'Infectiologie Charles Mérieux (CICM), University of Antananarivo, 101, Antananarivo, Madagascar., Rakotozafy RM; Department of Microbiology and Parasitology, University of Antananarivo, 101, Antananarivo, Madagascar., Soloniaina PR; Department of Microbiology and Parasitology, University of Antananarivo, 101, Antananarivo, Madagascar., Rakotozandrindrainy N; Department of Microbiology and Parasitology, University of Antananarivo, 101, Antananarivo, Madagascar., Rausche P; Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research (DZIF), Hamburg-Borstel-Lübeck-Riems, Germany., Doumbia CO; Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research (DZIF), Hamburg-Borstel-Lübeck-Riems, Germany.; University Clinical Research Centre (UCRC), University of Sciences Technics and Technologies of Bamako (USTTB), Bamako, Mali., Jaeger A; Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research (DZIF), Hamburg-Borstel-Lübeck-Riems, Germany., Zerbo A; Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research (DZIF), Hamburg-Borstel-Lübeck-Riems, Germany., von Thien H; German Centre for Infection Research (DZIF), Hamburg-Borstel-Lübeck-Riems, Germany.; Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands., Klein P; Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research (DZIF), Hamburg-Borstel-Lübeck-Riems, Germany., van Dam G; Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands., Tannich E; National Reference Centre for Tropical Pathogens (NRC), Hamburg, Germany., Schwarz NG; Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research (DZIF), Hamburg-Borstel-Lübeck-Riems, Germany., Lorenz E; Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research (DZIF), Hamburg-Borstel-Lübeck-Riems, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany., May J; Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; German Centre for Infection Research (DZIF), Hamburg-Borstel-Lübeck-Riems, Germany.; Department of Tropical Medicine I, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Rakotozandrindrainy R; Department of Microbiology and Parasitology, University of Antananarivo, 101, Antananarivo, Madagascar., Fusco D; Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. fusco@bnitm.de.; German Centre for Infection Research (DZIF), Hamburg-Borstel-Lübeck-Riems, Germany. fusco@bnitm.de.
Jazyk: angličtina
Zdroj: Infectious diseases of poverty [Infect Dis Poverty] 2023 Apr 25; Vol. 12 (1), pp. 44. Date of Electronic Publication: 2023 Apr 25.
DOI: 10.1186/s40249-023-01094-z
Abstrakt: Background: The goal to eliminate the parasitic disease of poverty schistosomiasis as a public health problem is aligned with the 2030 United Nations agenda for sustainable development goals, including universal health coverage (UHC). Current control strategies focus on school-aged children, systematically neglecting adults. We aimed at providing evidence for the need of shifting the paradigm of schistosomiasis control programs from targeted to generalized approaches as key element for both the elimination of schistosomiasis as a public health problem and the promotion of UHC.
Methods: In a cross-sectional study performed between March 2020 and January 2021 at three primary health care centers in Andina, Tsiroanomandidy and Ankazomborona in Madagascar, we determined prevalence and risk factors for schistosomiasis by a semi-quantitative PCR assay from specimens collected from 1482 adult participants. Univariable and multivariable logistic regression were performed to evaluate odd ratios.
Results: The highest prevalence of S. mansoni, S. haematobium and co-infection of both species was 59.5%, 61.3% and 3.3%, in Andina and Ankazomborona respectively. Higher prevalence was observed among males (52.4%) and main contributors to the family income (68.1%). Not working as a farmer and higher age were found to be protective factors for infection.
Conclusions: Our findings provide evidence that adults are a high-risk group for schistosomiasis. Our data suggests that, for ensuring basic health as a human right, current public health strategies for schistosomiasis prevention and control need to be re-addressed towards more context specific, holistic and integrated approaches.
(© 2023. The Author(s).)
Databáze: MEDLINE
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