Antimicrobial effect of quercetin against Streptococcus pneumoniae.

Autor: Willian de Alencar Pereira E; Virology Laboratory, Graduate Program in Microbial Biology, Brazil. Electronic address: eduprowork93@hotmail.com., Fontes VC; Virology Laboratory, Graduate Program in Microbial Biology, Brazil. Electronic address: valeria.cfontes@gmail.com., da Fonseca Amorim EA; Laboratory of Environmental Microbiology, Graduate Program in Microbial Biology, Brazil. Electronic address: erika.miranda@ceuma.br., de Miranda RCM; Laboratory of Environmental Microbiology, Graduate Program in Microbial Biology, Brazil. Electronic address: rita.miranda@ceuma.br., Carvalho RC; Center for Biological and Health Sciences, Federal University of Maranhão, Brazil. Electronic address: carvalho.rafael@ufma.br., de Sousa EM; Virology Laboratory, Graduate Program in Microbial Biology, Brazil. Electronic address: eduardo.sousa@ceuma.br., Cutrim SCPF; Virology Laboratory, Graduate Program in Microbial Biology, Brazil. Electronic address: sucafe@alumni.usp.br., Alves Lima CZGP; Center for Biological and Health Sciences, Federal University of Maranhão, Brazil. Electronic address: claudiazeneida0@yahoo.com.br., de Souza Monteiro A; Laboratory of Applied Microbiology, Graduate Program in Microbial Biology, Brazil. Electronic address: andrea.monteiro@ceuma.br., Neto LGL; Virology Laboratory, Graduate Program in Microbial Biology, Brazil. Electronic address: lidio.neto@outlook.com.
Jazyk: angličtina
Zdroj: Microbial pathogenesis [Microb Pathog] 2023 Jul; Vol. 180, pp. 106119. Date of Electronic Publication: 2023 Apr 23.
DOI: 10.1016/j.micpath.2023.106119
Abstrakt: Streptococcus pneumoniae is a bacterium that causes serious infections, including pneumonia. The limited range of available vaccines and the rise of antibiotic-resistant bacteria mean that new treatments are needed. This study looked at the potential of quercetin as an antimicrobial agent against S. pneumoniae in both isolation and in biofilms. The researchers used microdilution tests, checkerboard assays, and death curve assays, as well as in silico and in vitro cytotoxicity evaluations. They found that quercetin at a concentration of 125.0 μg/mL had both inhibitory and bactericidal effects against S. pneumoniae, and these effects were increased when quercetin was combined with ampicillin. Quercetin also reduced the growth of pneumococcal biofilms. In addition, quercetin (absence or in combination with ampicillin) reduced the death time of Tenebrio molitor larvae compared to the infection control. The study also demonstrated that quercetin had low toxicity in both in silico and in vivo assays, suggesting that it could be a promising treatment for infections caused by S. pneumoniae.
Competing Interests: Declaration of competing interest The authors declare that they have no know competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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