LC-HRMS Profiling and Phenolic Content, Cholinesterase, and Antioxidant Activities of Terminalia citrina.

Autor: Özler E; Gumushane University, Institute of Science and Technology, 29100, Gumushane, Turkey., Topal F; Gumushane University, Faculty of Engineering and Natural Sciences, Food Engineering, 29100, Gumushane, Turkey.; Gumushane University, Department of Chemical and Chemical Processing Technologies, Laboratory Technology Program, 29100, Gumushane, Turkey., Topal M; Gumushane University, Vocational School of Health Services, 29100, Gumushane, Turkey., Öztürk Sarıkaya SB; Gumushane University, Faculty of Engineering and Natural Sciences, Food Engineering, 29100, Gumushane, Turkey.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2023 Jun; Vol. 20 (6), pp. e202201250. Date of Electronic Publication: 2023 May 12.
DOI: 10.1002/cbdv.202201250
Abstrakt: Terminalia citrina (T. citrina) belongs to the Combretaceae family and is included in the class of medicinal plants in tropical countries such as Bangladesh, Myanmar, and India. The antioxidant activities of lyophilized water (WTE) and alcohol extracts (ETE) of T. citrina fruits, their phenolic content by LC-HRMS, and their effects on cholinesterases (ChEs; AChE, acetylcholinesterase, and BChE, butyrylcholinesterase) were investigated. Especially ten different analytical methods were applied to determine the antioxidant capacity. Compared with similar studies for natural products in the literature, it was determined that both WTE and ETE exhibited strong antioxidant capacity. Syringe and ellagic acids were higher than other acids in ETE and WTE. IC 50 values for ETE and WTE in DPPH radical and ABTS⋅ + scavenging activities were calculated as 1.69-1.68 μg mL -1 and 6.79-5.78 μg mL -1 , respectively. The results of the biological investigations showed that ETE and WTE had an inhibition effect against ChEs, with IC 50 values of 94.87 and 130.90 mg mL -1 for AChE and 262.55 and 279.70 mg mL -1 for BChE, respectively. These findings indicate that with the prominence of herbal treatments, T. citrina plant may guide the literature in treating Alzheimer's Disease, preventing oxidative damage, and mitochondrial dysfunction.
(© 2023 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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