Poor Renal Function and a High Modified Glasgow Prognostic Score Are Predictive Factors for Nedaplatin/5-Fluorouracil Combination Therapy-induced Febrile Neutropenia.

Autor:	Hashizume J; Department of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki, Japan., Nambu M; Department of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki, Japan., Nakagawa H; Department of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki, Japan., Harasawa H; Department of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki, Japan., Kodama Y; Department of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki, Japan y-kodama@nagasaki-u.ac.jp.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2023 May; Vol. 43 (5), pp. 2309-2316.
DOI:	10.21873/anticanres.16395
Abstrakt:	Background/aim: Nedaplatin (NDP)/5-fluorouracil (5-FU) combination therapy frequently causes severe neutropenia and febrile neutropenia (FN). However, there is no consensus on the risk factors for FN caused by NDP/5-FU combination therapy. Mouse models of cancer cachexia are known to be susceptible to infections. Conversely, the modified Glasgow prognostic score (mGPS) is believed to reflect cancer cachexia. We hypothesized that mGPS is a predictive factor for FN caused by NDP/5-FU combination therapy. Patients and Methods: We analyzed the relationship between mGPS and FN in patients who received NDP/5-FU combination therapy at Nagasaki University Hospital using multivariate logistic analysis. Results: In total, 157 patients were studied, 20 of whom developed FN (12.7%). Multivariate analysis revealed that mGPS 1-2 [odds ratio (OR)=4.13, 95% confidence interval (CI)=1.42-12.02, p=0.009] and creatinine clearance <54.4 ml/min (OR=5.81, 95% CI=1.81-18.59, p=0.003) were significantly associated with the development of FN. Conclusion: Several guidelines suggest that patients receiving chemotherapy with an FN rate 10-20% should be considered for prophylactic granulocyte colony-stimulating factor (G-CSF), depending on the individual patient's risk of developing FN. When NDP/5-FU combination therapy is administered to patients with risk factors identified in this study, prophylactic administration of G-CSF should be considered. In addition, the neutrophil count and axillary temperature should be monitored more frequently. (Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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