The adenomatous polyposis coli protein 30 years on.

Autor: Abbott J; Division of Computational Biology & D'Arcy Thompson Unit, University of Dundee, Dow Street, Dundee, DD2 1 EH, United Kingdom. Electronic address: j.abbott@dundee.ac.uk., Näthke IS; Division of Molecular Cell and Developmental Biology, University of Dundee, Dow Street, Dundee DD2 1EH, United Kingdom. Electronic address: i.s.nathke@dundee.ac.uk.
Jazyk: angličtina
Zdroj: Seminars in cell & developmental biology [Semin Cell Dev Biol] 2023 Dec; Vol. 150-151, pp. 28-34. Date of Electronic Publication: 2023 Apr 22.
DOI: 10.1016/j.semcdb.2023.04.004
Abstrakt: Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago. Since then, the importance of APC in normal tissue homeostasis has been confirmed in a plethora of other (model) organisms spanning a large evolutionary space. APC is a multifunctional protein, with roles as a key scaffold protein in complexes involved in diverse signalling pathways, most prominently the Wnt signalling pathway. APC is also a cytoskeletal regulator with direct and indirect links to and impacts on all three major cytoskeletal networks. Correspondingly, a wide range of APC binding partners have been identified. Mutations in APC are extremely strongly associated with colorectal cancers, particularly those that result in the production of truncated proteins and the loss of significant regions from the remaining protein. Understanding the complement of its role in health and disease requires knowing the relationship between and regulation of its diverse functions and interactions. This in turn requires understanding its structural and biochemical features. Here we set out to provide a brief overview of the roles and function of APC and then explore its conservation and structure using the extensive sequence data, which is now available, and spans a broad range of taxonomy. This revealed conservation of APC across taxonomy and new relationships between different APC protein families.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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