Feasibility of clinical studies of chemical exchange saturation transfer magnetic resonance imaging of prostate cancer at 7 T.
Autor: | Reesink DJ; Department of Oncological Urology, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Arteaga de Castro CS; Department of Precision Imaging, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Van der Velden T; Department of Precision Imaging, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Van Vooren J; Department of Radiology, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Oost P; Department of Urology, Tergooi Hospital Hilversum, Hilversum, The Netherlands., Jonges TGN; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands., Lam MGEH; Department of Radiology, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., de Keizer B; Department of Radiology, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Willemse PM; Department of Oncological Urology, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Meijer RP; Department of Oncological Urology, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands., Klomp DWJ; Department of Precision Imaging, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands. |
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Jazyk: | angličtina |
Zdroj: | NMR in biomedicine [NMR Biomed] 2023 Oct; Vol. 36 (10), pp. e4958. Date of Electronic Publication: 2023 May 08. |
DOI: | 10.1002/nbm.4958 |
Abstrakt: | Chemical exchange saturation transfer (CEST) has been explored for differentiation between tumour and benign tissue in prostate cancer (PCa) patients. With ultrahigh field strengths such as 7-T, the increase of spectral resolution and sensitivity could allow for selective detection of amide proton transfer (APT) at 3.5 ppm and a group of compounds that resonate at 2 ppm (i.e., [poly]amines and/or creatine). The potential of 7-T multipool CEST analysis of the prostate and the detection of PCa was studied in patients with proven localised PCa who were scheduled to undergo robot-assisted radical prostatectomy (RARP). Twelve patients were prospectively included (mean age 68.0 years, mean serum prostate-specific antigen 7.8ng/mL). A total of 24 lesions larger than 2 mm were analysed. Used were 7-T T2-weighted (T2W) imaging and 48 spectral CEST points. Patients received 1.5-T/3-T prostate magnetic resonance imaging and galium-68-prostate-specific membrane antigen-positron emission tomography/computerised tomography to determine the location of the single-slice CEST. Based on the histopathological results after RARP, three regions of interest were drawn on the T2W images from a known malignant zone and benign zone in the central and peripheral zones. These areas were transposed to the CEST data, from which the APT and 2-ppm CEST were calculated. The statistical significance of the CEST between the central zone, the peripheral zone, and tumour was calculated using a Kruskal-Wallis test. The z-spectra showed that APT and even a distinct pool that resonated at 2 ppm were detectable. This study showed a difference trend in the APT levels, but no difference in the 2-ppm levels when tested between the central zone, the peripheral zone, and tumour (H(2) = 4.8, p = 0.093 and H(2) = 0.86, p = 0.651, respectively). Thus, to conclude, we could most likely detect APT and amines and/or creatine levels noninvasively in prostate using the CEST effect. At group level, CEST showed a higher level of APT in the peripheral versus the central zone; however, no differences of APT and 2-ppm levels were observed in tumours. (© 2023 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.) |
Databáze: | MEDLINE |
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