Prevalence and risk factors for dementia in the Tibetan region: A population-based cross-sectional study.

Autor: Mima D; Department of Neurology of People's Hospital of Tibet Autonomous Region, Lhasa, Tibet Autonomous Region 850001, PR China., Wang LP; Department of Neurology, Peking University Third Hospital, 10091, PR China. Electronic address: dianer@126.com., Zhai Y; Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, PR China., De Q; People's Hospital of Qushui County, Lhasa, Tibet Autonomous Region 850600, PR China., Ba S; People's Hospital of Dagze County, Lhasa, Tibet Autonomous Region 850100, PR China., Da G; People's Hospital of Linzhou County, Lhasa, Tibet Autonomous Region 851600, PR China., Wang BY; Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province 150001, PR China., Zhao JB; Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province 150001, PR China., Tang Y; Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, PR China. Electronic address: tangyingty8@outlook.com.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2023 Aug 01; Vol. 334, pp. 159-165. Date of Electronic Publication: 2023 Apr 23.
DOI: 10.1016/j.jad.2023.04.075
Abstrakt: Background: As China's population ages, the nationwide prevalence of dementia is increasing. However, the epidemiology of dementia among the Tibetan population remains unclear.
Objective: A cross-sectional study was conducted involving 9116 participants aged >50 years in the Tibetan population to investigate the risk factors and prevalence of dementia among this population. Permanent residents of the region were invited to participate, and the response rate was 90.7 %.
Methods: The participants underwent neuropsychological testing and clinical assessments, from which physical measurements (e.g., body mass index, blood pressure), demographic information (e.g., gender, age), and lifestyle details (e.g., family living arrangement, smoking, alcohol arrangement) were recorded. Dementia diagnoses were made using the standard consensus diagnostic criteria. The risk factors of dementia were identified using stepwise multiple logistic regression.
Results: The average age of the participants was 63.71 (standard deviation = 9.36), and there were 44.86 % males. The prevalence of dementia was 4.66 %. The multivariate logistic regression analysis revealed that older age, unmarried status, lower education level, obesity, hypertension, diabetes, coronary heart disease, cerebral vascular disease, and HAPC were independently and positively associated with dementia (P < 0.05). However, no association was found between the frequency of religious activities and the prevalence of dementia in this population (P > 0.05).
Conclusions: There exist a number of contributory risk factors for dementia in the Tibetan population, with variations associated with high altitude, religious activities (i.e., scripture turning, chanting, spinning Buddhist beads, and bowing), and dietary habits. These findings suggest that social activities, such as religious activities, are protective factors for dementia.
Competing Interests: Conflict of interest The authors declare that they have no competing interests.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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