Development and implementation of a significantly low-cost 3D bioprinter using recycled scrap material.

Autor:	Gomes Gama JF; Laboratory of Cellular Communication, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Dias EA; Laboratory of Cellular Communication, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Aguiar Coelho RMG; Laboratory of Cellular Communication, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Chagas AM; Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, United Kingdom.; TReND in Africa, Brighton, United Kingdom.; Biomedical Science Research and Training Center, Yobe State University, Damaturu, Nigeria., Aguiar Coelho Nt J; Laboratory of Cellular Communication, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; National Institute of Industrial Property- INPI and Veiga de Almeida University, Rio de Janeiro, Brazil., Alves LA; Laboratory of Cellular Communication, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2023 Apr 07; Vol. 11, pp. 1108396. Date of Electronic Publication: 2023 Apr 07 (Print Publication: 2023).
DOI:	10.3389/fbioe.2023.1108396
Abstrakt:	The field of 3D bioengineering proposes to effectively contribute to the manufacture of artificial multicellular organ/tissues and the understanding of complex cellular mechanisms. In this regard, 3D cell cultures comprise a promising bioengineering possibility for the alternative treatment of organ function loss, potentially improving patient life expectancies. Patients with end-stage disease, for example, could benefit from treatment until organ transplantation or even undergo organ function restoration. Currently, 3D bioprinters can produce tissues such as trachea cartilage or artificial skin. Most low-cost 3D bioprinters are built from fused deposition modeling 3D printer frames modified for the deposition of biologically compatible material, ranging between $13.000,00 and $300.000,00. Furthermore, the cost of consumables should also be considered as they, can range from $3,85 and $100.000,00 per gram, making biomaterials expensive, hindering bioprinting access. In this context, our report describes the first prototype of a significantly low-cost 3D bioprinter built from recycled scrap metal and off-the-shelf electronics. We demonstrate the functionalized process and methodology proof of concept and aim to test it in different biological tissue scaffolds in the future, using affordable materials and open-source methodologies, thus democratizing the state of the art of this technology. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Gomes Gama, Dias, Aguiar Coelho, Chagas, Aguiar Coelho Nt and Alves.)
Databáze:	MEDLINE
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