Osteoimmunology: The effect of autoimmunity on fracture healing and skeletal analysis.
| Autor: | Lončar SR; Centre for Anatomy and Human Identification, School of Science and Engineering, University of Dundee, Scotland, United Kingdom.; Department of Anatomy, University of Otago, New Zealand., Halcrow SE; Department of Anatomy, University of Otago, New Zealand., Swales D; Centre for Anatomy and Human Identification, School of Science and Engineering, University of Dundee, Scotland, United Kingdom. |
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| Jazyk: | angličtina |
| Zdroj: | Forensic science international. Synergy [Forensic Sci Int Synerg] 2023 Mar 17; Vol. 6, pp. 100326. Date of Electronic Publication: 2023 Mar 17 (Print Publication: 2023). |
| DOI: | 10.1016/j.fsisyn.2023.100326 |
| Abstrakt: | Understanding factors that affect bone response to trauma is integral to forensic skeletal analysis. It is essential in forensic anthropology to identify if impaired fracture healing impacts assessment of post-traumatic time intervals and whether a correction factor is required. This paper presents a synthetic review of the intersection of the literature on the immune system, bone biology, and osteoimmunological research to present a novel model of interactions that may affect fracture healing under autoimmune conditions. Results suggest that autoimmunity likely impacts fracture healing, the pathogenesis however, is under researched, but likely multifactorial. With autoimmune diseases being relatively common, significant clinical history should be incorporated when assessing skeletal remains. Future research includes the true natural healing rate of bone; effect of autoimmunity on this rate; variation of healing with different autoimmune diseases; and if necessary, development of a correction factor on the natural healing rate to account for impairment in autoimmunity. Competing Interests: The authors have no competing interests to declare. (© 2023 The Authors.) |
| Databáze: | MEDLINE |
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