A Candidate microRNA Profile for Early Diagnosis of Sporadic Alzheimer's Disease.

Autor: Tsamou M; ToxGenSolutions (TGS), Maastricht, The Netherlands., Kalligerou F; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece., Ntanasi E; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece., Scarmeas N; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.; Department of Neurology, Columbia University, New York, NY, USA., Skalicky S; TamiRNA, Vienna, Austria., Hackl M; TamiRNA, Vienna, Austria., Roggen EL; ToxGenSolutions (TGS), Maastricht, The Netherlands.
Jazyk: angličtina
Zdroj: Journal of Alzheimer's disease reports [J Alzheimers Dis Rep] 2023 Apr 03; Vol. 7 (1), pp. 235-248. Date of Electronic Publication: 2023 Apr 03 (Print Publication: 2023).
DOI: 10.3233/ADR-230001
Abstrakt: Background: Late-onset or sporadic Alzheimer's disease (sAD) is a neurodegenerative disease leading to cognitive impairment and memory loss. The underlying pathological changes take place several years prior to the appearance of the first clinical symptoms, however, the early diagnosis of sAD remains obscure.
Objective: To identify changes in circulating microRNA (miR) expression in an effort to detect early biomarkers of underlying sAD pathology.
Methods: A set of candidate miRs, earlier detected in biofluids from subjects at early stage of sAD, was linked to the proposed tau-driven adverse outcome pathway for memory loss. The relative expression of the selected miRs in serum of 12 cases (mild cognitive impairment, MCI) and 27 cognitively normal subjects, recruited within the ongoing Aiginition Longitudinal Biomarker Investigation Of Neurodegeneration (ALBION) study, was measured by RT-qPCR. Data on the protein levels of amyloid-β (Aβ 42 ) and total/phosphorylated tau (t-tau/p-tau), in cerebrospinal fluid (CSF), and the cognitive z-scores of the participants were also retrieved.
Results: Each doubling in relative expression of 13 miRs in serum changed the odds of either having MCI (versus control), or having pathological Aβ 42 or pathological Aβ 42 and tau (versus normal) proteins in their CSF, or was associated with the global composite z-score.
Conclusion: These candidate human circulating miRs may be of great importance in early diagnosis of sAD. There is an urgent need for confirming these proposed early predictive biomarkers for sAD, contributing not only to societal but also to economic benefits.
Competing Interests: The authors have no conflict of interest to report.
(© 2023 – The authors. Published by IOS Press.)
Databáze: MEDLINE
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