Danish Population Based Study of Familial Epilepsy and Childhood Cancer.

Autor:	Platamone C; UCLA School of Public Health: University of California Los Angeles Jonathan and Karin Fielding School of Public Health., Huang X; UCLA School of Public Health: University of California Los Angeles Jonathan and Karin Fielding School of Public Health., Mazumder R; David Geffen School of Medicine: University of California Los Angeles David Geffen School of Medicine., Ritz B; UCLA School of Public Health: University of California Los Angeles Jonathan and Karin Fielding School of Public Health., Olsen J; Aarhus University Department of Clinical Medicine: Aarhus Universitet Institut for Klinisk Medicin., Hansen J; Danish Cancer Society: Kraeftens Bekaempelse., Saechao C; UCLA Health System: University of California Los Angeles Health System., Heck JE; UCLA School of Public Health: University of California Los Angeles Jonathan and Karin Fielding School of Public Health.
Jazyk:	angličtina
Zdroj:	Research square [Res Sq] 2023 Apr 14. Date of Electronic Publication: 2023 Apr 14.
DOI:	10.21203/rs.3.rs-2500755/v1
Abstrakt:	Objective: Results from studies investigating the association between maternal or child epilepsy, use of anticonvulsants in pregnancy, and childhood cancer are inconsistent and at times contradictory. Methods: Linking Danish national databases, we obtained epilepsy and childhood cancer diagnoses, and anticonvulsant use data. We estimated adjusted odds ratios of all or specific childhood cancers in relation to maternal or child epilepsy and anticonvulsant therapies using conditional logistic regression. Results: Maternal epilepsy was positively associated with all childhood cancers in offspring, specifically, with acute lymphoblastic leukemia (Odds Ratio (OR) = 1.68, 95% Confidence Interval (CI) = 1.16, 2.43) and Wilms tumor (OR = 2.13, 95%CI = 0.97, 4.68). When considering maternal ever (lifetime) ingestion of anticonvulsants, a positive association was found with all cancers (OR = 1.15, 95%CI = 1.01, 1.31), and central nervous system tumors (OR = 1.32, 95%CI = 1.03, 1.69) as well as neuroblastoma (OR = 2.05, 95%CI = 1.29, 3.28) among offspring. Maternal anticonvulsant use before or during the index pregnancy was related to CNS tumors in offspring (OR = 1.78, 95%CI = 0.99, 3.21), however the confidence interval included the null. Significance: Maternal use of certain anticonvulsant medications may be a risk factor for cancer in offspring. Medical providers may need to consider what type of treatments to prescribe to pregnant mothers with epilepsy. Competing Interests: Competing Interests There are no conflicts of interest to declare. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.
Databáze:	MEDLINE
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