No apparent role for the Wari insulator in transcriptional regulation of the endogenous white gene of Drosophila melanogaster .
Autor: | Born G; Biozentrum der Universität Basel, Basel, Switzerland.; Arcondis, Reinach, Switzerland., Bieli D; Biozentrum der Universität Basel, Basel, Switzerland.; Mabylon AG, Schlieren, Switzerland., Metzler M; Biozentrum der Universität Basel, Basel, Switzerland.; Oliver Wyman AG, Zürich, Switzerland., Gohl DM; University of Minnesota Genomics Center, Minneapolis, MN, USA., Affolter M; Biozentrum der Universität Basel, Basel, Switzerland., Müller M; Biozentrum der Universität Basel, Basel, Switzerland. |
---|---|
Jazyk: | angličtina |
Zdroj: | MicroPublication biology [MicroPubl Biol] 2023 Apr 05; Vol. 2023. Date of Electronic Publication: 2023 Apr 05 (Print Publication: 2023). |
DOI: | 10.17912/micropub.biology.000702 |
Abstrakt: | Chromatin insulators have been proposed to play an important role in chromosome organization and local regulatory interactions. In Drosophila , one of these insulators is known as Wari. It is located immediately downstream of the 3' end of the white transcription unit. Wari has been proposed to interact with the white promoter region, thereby facilitating recycling of the RNA polymerase machinery. We have tested this model by deleting the Wari insulator at the endogenous white locus and could not detect a significant effect on eye pigmentation. Competing Interests: The authors declare that there are no conflicts of interest present. (Copyright: © 2023 by the authors.) |
Databáze: | MEDLINE |
Externí odkaz: |