Photobiomodulation Therapy for Multiple Painful Fixed Drug Eruptions: The First Case Report.

Autor: Palma LF; Department of Pathology, Federal University of São Paulo, São Paulo, SP, Brazil., Campos L; Graduate Program in Implantology, University of Santo Amaro, School of Dentistry, São Paulo, SP, Brazil., de Oliveira SF; Graduate Dentistry Program, Ibirapuera University, São Paulo, SP, Brazil., Penido L; Dermatology Center, São Camilo Hospital, São Paulo, SP, Brazil., Morimoto S; School of Dentistry, Department of Orthodontics and Pediatric Dentistry, University of São Paulo, São Paulo, SP, Brazil., de Moraes LOC; Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Journal of lasers in medical sciences [J Lasers Med Sci] 2023 Feb 25; Vol. 14, pp. e4. Date of Electronic Publication: 2023 Feb 25 (Print Publication: 2023).
DOI: 10.34172/jlms.2023.04
Abstrakt: Introduction: Fixed drug eruption (FDE), a very specific adverse drug reaction and one of the most common types of drug eruption, generally resolves spontaneously within 7-10 days upon withdrawal of the causative agent; however, extensive and severe cases may also require systemic drug therapy. The present study aimed to report a case in which a broad spectrum of severe, painful lesions of FDE was managed with photobiomodulation therapy (PBMT). Case Report: A 31-year-old Caucasian woman presented with many extremely painful mucocutaneous lesions of FDE which had arisen 8 days before, following a long period of hospitalization. The lesions were not responsive to either corticosteroids or analgesics within 5 days, and then seven daily sessions of PBMT were proposed. Pain alleviation was achieved on the 1 st day of PBMT, and the lesions showed an advanced course of healing on the 3 rd day. Within 7 days of PBMT, the lesions were almost completely repaired. In a 3-month follow-up period, no relapse of any FDE lesion was reported. Conclusion: PBMT may be a promising strategy for the management of painful lesions of FDE refractory to conventional medication therapy. However, further studies are needed to confirm this hypothesis.
Competing Interests: No potential conflict of interest was reported by the authors.
(Copyright © 2023 J Lasers Med Sci.)
Databáze: MEDLINE
Externí odkaz: