| Autor: |
Thuy NTT; Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; Joint Vietnam - Russia Tropical Science and Technology Research Center, Hanoi, Vietnam., Hien HTM; Institute of Biotechnology, VAST, Hanoi, Vietnam., Ha NC; Institute of Biotechnology, VAST, Hanoi, Vietnam., Thom LT; Institute of Biotechnology, VAST, Hanoi, Vietnam., Hong DD; Institute of Biotechnology, VAST, Hanoi, Vietnam., Thinh NV; Joint Vietnam - Russia Tropical Science and Technology Research Center, Hanoi, Vietnam., Dan NT; Joint Vietnam - Russia Tropical Science and Technology Research Center, Hanoi, Vietnam., Hoi ND; Joint Vietnam - Russia Tropical Science and Technology Research Center, Hanoi, Vietnam., Loan VT; Joint Vietnam - Russia Tropical Science and Technology Research Center, Hanoi, Vietnam., Quang HD; Joint Vietnam - Russia Tropical Science and Technology Research Center, Hanoi, Vietnam., Hang DTT; Institute of Marine Biochemistry, VAST, Hanoi, Vietnam., Kiem PV; Institute of Marine Biochemistry, VAST, Hanoi, Vietnam., Tai BH; Institute of Marine Biochemistry, VAST, Hanoi, Vietnam., Hang NTM; Institute of Marine Biochemistry, VAST, Hanoi, Vietnam., Dat NT; Center for Research and Technology Transfer, VAST, Hanoi, Vietnam., Nhiem NX; Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.; Institute of Marine Biochemistry, VAST, Hanoi, Vietnam. |
| Abstrakt: |
One new indol, N -methoxymethyltryptophol ( 1 ), one new phenolic, (2 R )-2-(4-hydroxyphenyl)ethyl 2-hydroxy-3-phenylpropanoate ( 2 ) and fifteen known compounds ( 3-17 ) were isolated from the methanol extract of the fermentation of marine microalgae Aurantiochytrium sp. SC145. Their structures were elucidated by 1D-, 2D-NMR spectroscopic analysis, HR-ESI-MS, quantum chemical calculation methods and by comparing their NMR data with those reported in the literature. All compounds were evaluated for their antimicrobial activities against microorganisms. Compounds 2, 3 and 11 significantly exhibited antimicrobial activities on all tested Gram-(+), Gram-(-) bacteria and the yeast C. albicans with MIC values ranging from 32 to 256 µg/mL. |
