Pyroptosis-related gene signature elicits immune response in rosacea.

Autor: Hu XM; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China., Zheng SY; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China., Mao R; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China., Zhang Q; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China., Wan XX; Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha, China., Zhang YY; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China., Li J; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China., Yang RH; Department of Burn and Plastic Surgery, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China., Xiong K; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China.; Hunan Key Laboratory of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Emergency and Trauma, Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou, China.
Jazyk: angličtina
Zdroj: Experimental dermatology [Exp Dermatol] 2024 Jan; Vol. 33 (1), pp. e14812. Date of Electronic Publication: 2023 Apr 22.
DOI: 10.1111/exd.14812
Abstrakt: Rosacea is a complex chronic inflammatory skin disorder with high morbidity. Pyroptosis is known as a regulated inflammatory cell death. While its association with immune response to various inflammatory disorders is well established, little is known about its functional relevance of rosacea. So, we aimed to explore and enrich the pathogenesis involved in pyroptosis-related rosacea aggravations. In this study, we evaluated the pyroptosis-related patterns of rosacea by consensus clustering analysis of 45 ferroptosis-related genes (FRGs), with multiple immune cell infiltration analysis to identify the pyroptosis-mediated immune response in rosacea using GSE65914 dataset. The co-co-work between PRGs and WGCNA-revealed hub genes has established using PPI network. FRG signature was highlighted in rosacea using multi-transcriptomic and experiment analysis. Based on this, three distinct pyroptosis-related rosacea patterns (non/moderate/high) were identified, and the notably enriched pathways have revealed through GO, KEGG and GSEA analysis, especially immune-related pathways. Also, the XCell/MCPcount/ssGSEA/Cibersort underlined the immune-related signalling (NK cells, Monocyte, Neutrophil, Th2 cells, Macrophage), whose hub genes were identified through WGCNA (NOD2, MYD88, STAT1, HSPA4, CXCL8). Finally, we established a pyroptosis-immune co-work during the rosacea aggravations. FRGs may affect the progression of rosacea by regulating the immune cell infiltrations. In all, pyroptosis with its mediated immune cell infiltration is a critical factor during the development of rosacea.
(© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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